Investigation of the COMT Val158Met variant association with age of onset of psychosis, adjusting for cannabis use
Rohit Jaibhagwan Lodhi, Yabing Wang, David Rossolatos, Georgina MacIntyre, Alexandra Bowker, Candice E. Crocker, Hongyan Ren, Aleksandra Dimitrijević, Darren A. Bugbee, Alexandra Loverock, Brett Majeau, Sudhakar Sivapalan, Virginia M. Newton, Philip G. Tibbo, Scot E. Purdon, Katherine Jean Aitchison
Brain and Behavior October 6, 2017 DOI: 10.1002/brb3.850 (opens in new tab)
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Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 169 |
| Population | Canadian Caucasian subjects with psychosis |
| Measures | Structured Clinical Interview for DSM-IV, self-report computerized questionnaire, SNaPshot and TaqMan assays |
| Topics | Cannabis |
| Citations | 12 |
| Key findings | Among participants who used cannabis before age 20, the COMT rs4680 genotype showed a trend-level association with age of psychosis onset, with median onset ages of 19.37, 20.95, and 21.24 years for Val/Val, Val/Met, and Met/Met, respectively (log-rank p = .051). The authors indicate that further investigation of this association is needed. |
Abstract
Abstract Objective COMT rs4680 (Val158Met) genotype moderates the effect of cannabis on the age of onset of psychosis (AoP). We investigated the association between rs4680 and AoP, after adjusting for relevant covariates, in a Canadian Caucasian sample.
Methods: One hundred and sixty‐nine subjects with psychosis were recruited. AoP, defined as age of DSM‐IV diagnosis was established using the Structured Clinical Interview for DSM‐IV. Cannabis use data were collected using a self‐report computerized questionnaire. DNA was extracted from saliva and genotyping of the COMT Val158Met polymorphism was done by SNaPshot and TaqMan assays. Logistic regression and Kaplan–Meier analysis results are reported.
Results: In those who had used cannabis before 20 years of age, rs4680 had a trend level effect on AoP (median AoP: Val/Val < Val/Met < Met/Met 19.37, 20.95, 21.24 years, respectively; log‐rank test p = .051).
Conclusion: Our data are indicative of the need to further investigate the association between the COMT rs4680 variant and AoP in the context of adolescent cannabis use.
Comparable studies
Other observational and cohort studies on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| High-potency cannabis and the risk of psychosis People with first episode of psychosis and healthy controls from the local population | 2009 | Case-control study | n = 454 |
| Ayahuasca-Assisted Therapy for Addiction: Results from a Preliminary Observational Study in Canada Rural aboriginal population | 2013 | Observational study | |
| Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) Otherwise healthy young people | 2000 | Observational | |
| Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study Individuals from the general population in Germany aged 14-24 at baseline | 2011 | Observational cohort | n = 1,923 |
| Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: follow-up study of 535 incident cases Patients treated for cannabis-induced psychotic symptoms in Denmark between 1994 and... | 2005 | Observational cohort | n = 535 |
Citations in the library
Cited by 3
- Cannabis induced psychosis: a systematic review on the role of genetic polymorphisms. Pharmacological Research May 1, 2022
- Cannabis use in Adolescence and Risk of Psychosis: Are there Factors that Moderate this Relationship? A Systematic Review and Meta-Analysis Substance Abuse February 22, 2021
- Factors Moderating the Association between Cannabis Use and Psychosis Risk: A Systematic Review Brain Science February 1, 2020
Cites 7
- Causal association between cannabis and psychosis: examination of the evidence The British Journal of Psychiatry January 30, 2004
- High-potency cannabis and the risk of psychosis The British Journal of Psychiatry November 30, 2009
- COMT Val158Met moderation of cannabis‐induced psychosis: a momentary assessment study of ‘switching on’ hallucinations in the flow of daily life Acta Psychiatrica Scandinavica September 19, 2008
- Association Between Cannabis and Psychosis: Epidemiologic Evidence. Biological Psychiatry April 1, 2016
- Significant decreases in frontal and temporal [11C]-raclopride binding after THC challenge. Neuroimage May 6, 2010
and 2 more in the library