Mental representations enable the brain to transcend the immediacy of sensory input and operate on internal models of the world. Working memory (WM) provides the neural substrate that maintains, manipulates, and accesses these representations over behaviorally relevant timescales. Early studies identified persistent neuronal activity in the dorsolateral prefrontal cortex as a key mechanism...
General anesthetics are routinely used to induce unconsciousness. While much is known about their effects on receptor function and the activity of individual neurons, much less is known about how these local effects are manifest at the level of largescale, distributed brain networks. Using functional magnetic resonance imaging (fMRI) with the common marmoset (Callithrix jacchus) we investigated...
Journal of NeuroscienceApril 9, 2025Audrey Dureux, Alessandro Zanini, Azadeh Jafari et al.3 citations
Auditory deficits are a well-known symptom in neuropsychiatric disorders such as schizophrenia. The noncompetitive N-methyl-d-aspartate receptor antagonist ketamine has been used to model sensory and cognitive deficits in nonhuman primates, but its whole-brain effects remain largely unknown. Here we employed ultra-high field functional magnetic resonance imaging at 9.4 T in awake male and...
Cognitive control is engaged by working memory processes and high-demand situations like antisaccade, where one must suppress a prepotent response. While it is known to be supported by the frontoparietal control network, how intra- and interareal dynamics contribute to cognitive control processes remains unclear. N-Methyl-d-aspartate glutamate receptors (NMDARs) play a key role in prefrontal...
Schizophrenia is known as a syndrome of dysconnection among brain regions. As a model for this syndrome, low doses of N-methyl-D-aspartate (NMDA) receptor antagonists, such as ketamine, produce schizophrenia-like symptoms and cognitive deficits in healthy humans and animals. One of such deficits is impaired working memory, a process that engages an extended network of both frontal and parietal...
SUMMARY The human default mode network (DMN) is engaged at rest and in cognitive states such as self-directed thoughts. Interconnected homologous cortical areas in primates constitute a network considered as the equivalent. Here, based on a cross-species comparison of the DMN between humans and non-hominoid primates (macaques, marmosets, and mouse lemurs), we report major dissimilarities in...
Faces are stimuli of critical importance for primates. The common marmoset (Callithrix jacchus) is a promising model for investigations of face processing, as this species possesses oculomotor and face processing networks resembling those of macaques and humans. Face processing is often disrupted in neuropsychiatric conditions such as schizophrenia (SZ) and thus it is important to recapitulate...