Ultra-high Field fMRI Reveals Effect of Ketamine on Vocal Processing in Common Marmosets.
Audrey Dureux, Alessandro Zanini, Azadeh Jafari, Stefan Everling
The Journal of neuroscience : the official journal of the Society for Neuroscience April 9, 2025 DOI: 10.1523/JNEUROSCI.0651-24.2025 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study with within-subject drug challenge Peer reviewed |
|---|---|
| Population | Awake male and female marmoset monkeys (Callithrix jacchus) |
| Intervention | Ketamine |
| Dose | subanesthetic dose |
| Topics | Ketamine Esketamine |
| Keywords | Auditory processing FMRI Marmoset monkeys Psychopharmacology Schizophrenia research Primate studies |
| Citations | 3 |
| Key findings | Ketamine broadly suppresses auditory brain activations in marmosets and alters processing in the mediodorsal thalamus and anterior cingulate cortex specifically for vocalizations, mirroring disruptions seen in schizophrenia. |
Abstract
Auditory deficits are a well-known symptom in neuropsychiatric disorders such as schizophrenia. The noncompetitive N-methyl-d-aspartate receptor antagonist ketamine has been used to model sensory and cognitive deficits in nonhuman primates, but its whole-brain effects remain largely unknown. Here we employed ultra-high field functional magnetic resonance imaging at 9.4 T in awake male and female marmoset monkeys (Callithrix jacchus) to compare brain activations to conspecific vocalizations, scrambled vocalizations, and nonvocal sounds following the administration of a subanesthetic dose of ketamine. Our findings reveal a broad suppression of activations across auditory regions following ketamine compared with saline. Additionally, we observed differential effects depending on the type of sound, with notable changes in the mediodorsal thalamus and anterior cingulate cortex, particularly during the processing of vocalizations. These findings suggest a potential overlap between the effects of ketamine and neural disruptions observed in schizophrenia, particularly affecting vocalization processing.