Examining what works for whom and how in mindfulness-based cognitive therapy (MBCT) for recurrent depression: moderated-mediation analysis in the PREVENT trial.
The British journal of psychiatry : the journal of mental science April 1, 2025 Jesus Montero-Marin, Verena Hinze, Shannon Maloney et al. 4 citations
Mindfulness skills mediate the effect of mindfulness-based cognitive therapy (MBCT) on depressive symptoms over 24 months, and this mediation is stronger for people with more severe depression. Among 424 adults with recurrent depression, those with higher severity showed an expected 10-point reduction on the Beck Depression Inventory-II, compared to a 3.5-point reduction for those with lower severity. The findings suggest MBCT with antidepressant tapering support works through a unique mechanism—mindfulness skills—that differs from maintenance medication alone, supporting personalized treatment for recurrent depression.