American Journal of Psychiatry
July 28, 2022
Joseph Wielgosz, Tammi R. A. Kral, David M Perlman et al.
21 citations
OBJECTIVE: Mindfulness-based interventions are widely used to target pain, yet their neural mechanisms of action are insufficiently understood. The authors studied neural and subjective pain response in a randomized active-control trial of mindfulness-based stress reduction (MBSR) alongside long-term meditation practitioners. METHODS: Healthy participants (N=115) underwent functional...
Frontiers in Psychology
January 28, 2021
Dylan Thomas Lott, Tenzin Yeshi, N. Norchung et al.
18 citations
Recent EEG studies on the early postmortem interval that suggest the persistence of electrophysiological coherence and connectivity in the brain of animals and humans reinforce the need for further investigation of the relationship between the brain’s activity and the dying process. Neuroscience is now in a position to empirically evaluate the extended process of dying and, more specifically,...
Journal of Traumatic Stress
August 1, 2014
Emma M Seppala, Jack B. Nitschke, Dana Tudorascu et al.
180 citations
Given the limited success of conventional treatments for veterans with posttraumatic stress disorder (PTSD), investigations of alternative approaches are warranted. We examined the effects of a breathing-based meditation intervention, Sudarshan Kriya yoga, on PTSD outcome variables in U.S. male veterans of the Iraq or Afghanistan war. We randomly assigned 21 veterans to an active (n = 11) or...
Neuroimage
2013
Antoine Lutz, Daniel R McFarlin, David M Perlman et al.
Experientially opening oneself to pain rather than avoiding it is said to reduce the mind's tendency toward avoidance or anxiety which can further exacerbate the experience of pain. This is a central feature of mindfulness-based therapies. Little is known about the neural mechanisms of mindfulness on pain. During a meditation practice similar to mindfulness, functional magnetic resonance...
Emotion
2010
David M Perlman, Tim V Salomons, Richard J. Davidson et al.
203 citations
Pain is an unpleasant sensory and emotional experience that can be regulated by many different cognitive mechanisms. We compared the regulatory qualities of two different meditation practices during noxious thermal stimuli: Focused Attention, directed at a fixation cross away from the stimulation, which could regulate negative affect through a sensory gating mechanism; and Open Monitoring,...
Neuroimage
September 1, 2009
Antoine Lutz, Lawrence L. Greischar, David M Perlman et al.
The brain and the cardiovascular system influence each other during the processing of emotion. The study of the interactions of these systems during emotion regulation has been limited in human functional neuroimaging, despite its potential importance for physical health. We have previously reported that mental expertise in cultivation of compassion alters the activation of circuits linked with...