Fine-tuning of dopamine receptor signaling with aripiprazole counteracts ketamine's dissociative action, but not its antidepressant effect.
Translational Psychiatry March 8, 2025 Daiki Nakatsuka, Taro Suwa, Yuichi Deguchi et al. 1 citation
Ketamine, a rapid-acting antidepressant, has undesirable psychotomimetic effects, including a dissociative effect. There is currently no effective strategy to suppress these side effects while preserving its antidepressant effect. Here, we investigated the effects of a D2/D3 receptor antagonist and partial agonists on the psychotomimetic and antidepressant effects of ketamine in mice and...
DOI: 10.1038/s41398-025-03284-9 (opens in new tab)
Full text (opens in new tab)
Ketamine therapy
Antidepressant medication
Mental health treatment
Psychiatric research
+1