Toxicology Reports
June 1, 2025
Leonardo Costalonga Rodrigues, Alexandre Barcia de Godoi, Viviane Cristina Fais et al.
4 citations
New psychoactive substances (NPS) have emerged as a significant public health concern, with synthetic cannabinoid receptor agonists (SCRAs) and ketamine derivatives being among the most frequently detected compounds in the forensic context worldwide. The Fish Embryo Acute Toxicity (FET) and Maximum Tolerated Concentration (MTC) tests are used to evaluate the acute toxicity of chemicals. In this...
Journal of Analytical Toxicology
June 11, 2024
Juliana Ribeiro Ibiapina Leitão Oliveira, Leonardo Costalonga Rodrigues, Júlia Martinelli Magalhães Kahl et al.
13 citations
New psychoactive substances (NPS) are often synthesized via small changes in the molecular structure, producing drugs whose effect and potency are not yet fully known. Ketamine is one of the oldest NPS, with therapeutic use in human and veterinary medicine authorized in several countries, being metabolized mainly into norketamine and 6-hydroxy-norketamine. Furthermore, two structural analogues...
Analytica Chimica Acta
May 1, 2024
André Luis Fabris, Stig Pedersen-Bjergaard, Elisabeth Leere Øiestad et al.
9 citations
Parallel artificial liquid membrane extraction (PALME) is a 96-well plate setup variant of liquid-phase microextraction. Basic or acidic analytes are extracted in neutral form from the sample, through a supported liquid membrane (SLM), and into aqueous acceptor. PALME is already considered a green extraction technique, but in the current conceptual work, we sought to make it even greener by...
Journal of Analytical Toxicology
August 29, 2023
Marilia Santoro Cardoso, Kelly Francisco da Cunha, Izabelly Geraldes Silva et al.
3 citations
Abstract Psilocin is an active substance and a dephosphorylated product of psilocybin formed after the ingestion of mushrooms. The low stability caused by the quick oxidation of this analyte requires sensitive methods for its determination in biological matrices. In this work, we described the development, optimization and validation of a method for the quantification of psilocin in authentic...
Forensic Science International
December 1, 2022
Luiz Ferreira Neves Junior, André Luis Fabris, Ingrid Lopes Barbosa et al.
10 citations
Lucy in the Sky with Diamonds, a John Lennon song that was a hit in the 1960s, was born amidst a social context enlightened by lysergic acid diethylamide (LSD). In Brazil, both the drug and the song were very popular at the time, although it gradually mitigated. Nevertheless, while the song remains out of the spotlight, LSD derivatives are currently gaining attention with the rising of the new...
Drug Testing and Analysis
March 1, 2021
Rafael Lanaro, Sueli Moreira Mello, Kelly Francisco da Cunha et al.
10 citations
Ayahuasca is a beverage obtained from Banisteriopsis caapi plus Psychotria viridis. B. caapi contains the β-carbolines harmine, harmaline, and tetrahydroharmine that are monoamine oxidase inhibitors and P. viridis contains N,N-dimethyltryptamine (DMT) that is responsible for the visionary effects of the beverage. Ayahuasca use is becoming a global phenomenon, and the recreational use of DMT and...
Journal of Analytical Toxicology
October 12, 2020
Kelly Francisco da Cunha, Karina Diniz Oliveira, Marilyn A. Huestis et al.
73 citations
New psychoactive substances (NPS) are a major public health problem, primarily due to the increased number of acute poisoning cases. Detection of these substances is a challenge. The aim of this research was to develop and validate a sensitive screening method for 104 drugs of abuse, including synthetic cannabinoids, synthetic cathinones, fentanyl analogues, phenethylamines and other abused...
Journal of Psychoactive Drugs
December 22, 2018
Sueli Moreira Mello, Paula Christiane Soubhia, Gabriela de Oliveira Silveira et al.
15 citations
Ayahuasca is a beverage obtained from decoctions of the liana Banisteriopsis caapi plus the shrub Psychotria viridis. This beverage contains a combination of monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) and N,N-dimethyltryptamine, the main substance responsible for its visionary effect. The ritualistic use of ayahuasca is becoming a global phenomenon. Most members of...
Environmental and Molecular Mutagenesis
November 29, 2018
Fábio Kummrow, Bianca S. Maselli, Rafael Lanaro et al.
9 citations
Ayahuasca is a beverage used in religious rituals of indigenous and nonindigenous groups, and its therapeutic potential has been investigated. Ayahuasca is obtained by decoction of the Banisteriopsis caapi that contains β‐carbolines (harmine, harmaline, and tetrahydroharmine) plus Psychotria viridis that contains N , N ‐dimethyltryptamine. Although plants used in folk medicine are recognized as...
Frontiers in Pharmacology
May 29, 2018
Elisangela Gouveia Cata-Preta, Yasmim A. Serra, Eliseu Da Cruz Moreira-Junior et al.
50 citations
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- and N,N-dimethyltryptamine(DMT)-containing plants, respectively. Accumulating evidence suggests that ayahuasca may have therapeutic effects on ethanol abuse. It is not known, however, whether its effects are dependent on the presence of DMT or if...
Journal of Psychoactive Drugs
March 15, 2015
Rafael Lanaro, Débora Bressanim de Aquino Calemi, Loraine Rezende Togni et al.
51 citations
The ritualistic use of ayahuasca is becoming a global phenomenon. This beverage contains a combination of monoamine oxidase inhibitors (harmine, harmaline, and tetrahydroharmine) and N,N-dimethyltryptamine, the main substance responsible for its visionary effect. The recreational use of similar alkaloids and N,N-dimethyltryptamine has increased in recent years, mainly because of their...
Physiology & Behavior
January 28, 2015
Alexandre J. Oliveira-Lima, Renato Antunes Dos Santos, A.w. Hollais et al.
91 citations
BackgroundHallucinogenic drugs were used to treat alcoholic patients in the past, and recent developments in the study of hallucinogens led to a renewal of interest regarding the application of these drugs in the treatment of addiction. In this scenario, accumulating evidence suggests that the hallucinogenic brew ayahuasca (Aya) may have therapeutic effects on substance abuse problems.MethodsWe...
Behavioural Processes
September 22, 2014
Tathiana A. Alvarenga, Daniel Ninello Polesel, Gabriela Matos et al.
10 citations
The ingestion of the beverage Ayahuasca usually occurs in religious ceremonies that are performed during the night leading to sleep deprivation. The purpose of the present study was to characterize the acute effects of Ayahuasca upon the sexual response of sleep deprived male rats. One group of sexually experienced male Wistar rats were submitted to a paradoxical sleep deprivation (PSD)...
Bioanalysis
July 1, 2012
Carolina Dizioli Rodrigues de Oliveira, Guilherme Gonçalves Okai, José Luiz Costa et al.
33 citations
The method proved to be simple, rapid and useful to estimate administered doses for further pharmacological and toxicological investigations of ayahuasca exposure.