Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase that has emerged as a key regulator of neurotransmission in complex cognitive processes. Its expression is altered in treated schizophrenia patients, and cannabinoids modulate CDK5 levels in the brain of rodents. However, the role of this kinase, and its interaction with cannabis use in first-episode psychosis (FEP) patients is still...
Abstract Background Despite the proliferation of new psychoactive substances (NPS) in recent years, there are many gaps in our understanding of the phenomena. Current methodologies still fail to provide timely and scientifically reliable knowledge between controlled trials and online data reports that lack analytical confirmation of the reported substances. This study tests a new online,...