PsychopharmacologyOctober 28, 2026Samantha N Melendez, Margy Y. Chen, Claire L. Pince et al.
Cannabis research is advancing rapidly, yet fundamental questions persist regarding the optimal design of human studies to empirically assess the potential harms and benefits of cannabis. There exist central methodological differences between studies that rely on controlled dose paradigms, ensuring internal validity, and those that utilize naturalistic, self-administration approaches which...
As cannabis products become increasingly accessible and novel modes of administration like dabbing and vaping gain popularity, understanding how these modes impact use experiences and abuse liability is crucial. Existing studies primarily utilized laboratory settings with lower-potency research-grade cannabis, failing to capture common modes among individuals who use higher-potency legal market...
Objective: Cannabis has been touted for a host of pharmacological and therapeutic effects and users commonly report reduced symptoms of physical and mental health conditions, including anxiety, depression, and chronic pain. While there is existing empirical evidence supporting these effects of cannabis use, little is known about the extent to which these effects result from pharmacological...