Controlling the uncontrollable? navigating naturalistic and controlled dosing in cannabis research
Psychopharmacology October 28, 2026 Samantha N Melendez, Margy Y. Chen, Claire L. Pince et al.
Cannabis research is advancing rapidly, yet fundamental questions persist regarding the optimal design of human studies to empirically assess the potential harms and benefits of cannabis. There exist central methodological differences between studies that rely on controlled dose paradigms, ensuring internal validity, and those that utilize naturalistic, self-administration approaches which...