PsychopharmacologyOctober 28, 2026Samantha N. Melendez, Margy Y. Chen, Claire L. Pince et al.
Cannabis research is advancing rapidly, yet fundamental questions persist regarding the optimal design of human studies to empirically assess the potential harms and benefits of cannabis. There exist central methodological differences between studies that rely on controlled dose paradigms, ensuring internal validity, and those that utilize naturalistic, self-administration approaches which...
RATIONALE An estimated two-thirds of medical cannabis users in the United States are motivated by chronic pain, but clinical guidance remains guarded as to whether the potential benefit of cannabinoids for pain outweighs potential risks, such as effects on cognition. OBJECTIVES In a study where participants experienced benefits of cannabinoids for pain and tension, we evaluated cannabis effects...