Evidence for case–control studies suggests that cannabis use is a risk factor for the development of psychosis. However, there have been limited prospective studies and the direction of this association remains controversial. The primary aim of the present study was to examine the association between cannabis use and the incidence of psychotic disorders in people at clinical high risk of...
As countries adopt more permissive cannabis policies, it is increasingly important to identify strategies that can reduce the harmful effects of cannabis use. This study aimed to determine if increasing the CBD content of cannabis can reduce its harmful effects. Forty-six healthy, infrequent cannabis users participated in a double-blind, within-subject, randomised trial of cannabis preparations...
Abstract Although clinical intervention at the clinical high risk stage has the potential to prevent the onset of psychosis, there are still no licensed pharmacological treatments for this purpose. The development of preventative treatments is informed by models of psychosis onset, especially those that reflect the time course and symptomatology of the disorder. This chapter describes four...