Natania A. Crane

2 papers in the library · publishing 2021-2026

Papers

Δ9-Tetrahydrocannabinol Alters Limbic and Frontal Functional Brain Connectomes Among Young Adult Cannabis Users.

Biological psychiatry. Cognitive neuroscience and neuroimaging May 1, 2026 Zachary Anderson, Matthew Gunn, Emily Jones et al.

A moderate oral dose of THC (7.5 mg) reduced resting-state functional connectivity within several brain networks, including corticostriatal circuits and networks involved in sensory processing, interoception, and spatial reasoning, in 33 healthy occasional young adult cannabis users. THC also decreased connectivity between two specific networks: one involving the anterior cingulate cortex and dorsal insula, and another involving the ventral insula and lingual gyrus. These connectivity changes were not related to subjective drug effects or recent cannabis use. The findings indicate that even a single moderate THC dose broadly disrupts intrinsic brain network connectivity.

DOI: 10.1016/j.bpsc.2025.09.005 Full text Cannabis Frequency Independent component analysis Resting state +2

Effect of Δ9-Tetrahydrocannabinol on Frontostriatal Resting State Functional Connectivity and Subjective Euphoric Response in Healthy Young Adults

Drug and Alcohol Dependence February 3, 2021 Natania A. Crane, K. Phan

An acute dose of THC, the main psychoactive component of cannabis, increased resting-state functional connectivity between the nucleus accumbens (NAcc) and medial prefrontal cortex (mPFC) in healthy young adults with limited cannabis use, compared to placebo. Participants receiving THC also reported higher subjective euphoria, and greater euphoria was linked to stronger NAcc-dorsal mPFC connectivity in the THC group but not the placebo group. These findings suggest THC may produce subjective and neural reward responses that contribute to cannabis's reinforcing properties.

DOI: 10.1016/j.drugalcdep.2021.108565 Full text Medicine Psychology