Imaging Neuroscience
2025
Sacha Haudry, Sophie Dautricourt, Julie Gonneaud et al.
Meditation training in older adults has been proposed as a non-pharmacological intervention to promote healthy aging and lower the risks of developing Alzheimer's disease (AD). Resting-state dynamic functional network connectivity (dFNC) highlighted two brain states, the "strongly connected" and "default mode network (DMN)-negatively connected" states, associated with protective factors for...
Scientific Reports
November 27, 2024
Sacha Haudry, Anne-Laure Turpin, Brigitte Landeau et al.
3 citations
Meditation is a mental training approach that can improve mental health and well-being in aging. Yet the underlying mechanisms remain unknown. The Medit-Ageing model stipulates that three mechanisms - attentional, constructive, and deconstructive - upregulate positive psycho-affective factors and downregulate negative ones. To test this hypothesis, we measured brain structural MRI and...
JAMA Network Open
July 3, 2023
Harriet Demnitz-King, Florence Requier, Tim Whitfield et al.
Nonpharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults. To investigate the effects of 18 months' meditation training and 18 months' non-native language training on cognition in older adults. This study was a secondary analysis of the Age-Well trial, an 18-month, observer-masked, randomized clinical trial with 3 parallel arms....
JAMA Neurology
October 10, 2022
Gaël Chételat, Antoine Lutz, Olga Klimecki et al.
45 citations
Importance: No lifestyle-based randomized clinical trial directly targets psychoaffective risk factors of dementia. Meditation practices recently emerged as a promising mental training exercise to foster brain health and reduce dementia risk. Objective: To investigate the effects of meditation training on brain integrity in older adults. Design, Setting, and Participants: Age-Well was a...
Alzheimer's Research & Therapy
September 6, 2022
Tim Whitfield, Harriet Demnitz-King, Marco Schlosser et al.
Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk of objective cognitive decline and incident dementia. Non-pharmacological interventions (including mindfulness-based and health self-management approaches) are a potential strategy to...
Neuropsychology Review
August 4, 2021
Tim Whitfield, Thorsten Barnhofer, Rebecca L. Acabchuk et al.
193 citations
Mindfulness-based programs (MBPs) are increasingly utilized to improve mental health. Interest in the putative effects of MBPs on cognitive function is also growing. This is the first meta-analysis of objective cognitive outcomes across multiple domains from randomized MBP studies of adults. Seven databases were systematically searched to January 2020. Fifty-six unique studies (n = 2,931) were...
Alzheimer s & Dementia
December 1, 2020
Tim Whitfield, Thorsten Barnhofer, Rebecca L. Acabchuk et al.
6 citations
Abstract Background The primary focus of mindfulness‐based program (MBP) research to date has been on mental health. More recently, attention has turned to putative effects on cognition. An evidence synthesis is required to answer the key question of ‘Do MBPs confer cognitive benefit, and if so, for whom?’ A particularly crucial distinction is whether benefits differ according to individuals’...