Journal of Neuroscience
October 6, 2010
Cullen L. Schmid, Laura M Bohn
172 citations
Hallucinogens mediate many of their psychoactive effects by activating serotonin 2A receptors (5-HT 2A R). Although serotonin is the cognate endogenous neurotransmitter and is not considered hallucinogenic, metabolites of serotonin also have high affinity at 5-HT 2A R and can induce hallucinations in humans. Here we report that serotonin differs from the psychoactive N -methyltryptamines by its...
Psychopharmacology
October 1, 2010
Anthony G Romano, Jennifer L Quinn, Luchuan Li et al.
42 citations
Parenteral injections of d-lysergic acid diethylamide (LSD), a serotonin 5-HT(2A) receptor agonist, enhance eyeblink conditioning. Another hallucinogen, (±)-1(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI), was shown to elicit a 5-HT(2A)-mediated behavior (head bobs) after injection into the hippocampus, a structure known to mediate trace eyeblink conditioning. This study aims...
Neuroscience
September 1, 2010
A B Klein, Martin A. Santini, Susana Aznar et al.
Changes in brain-derived neurotrophic factor (BDNF) expression have been implicated in the etiology of psychiatric disorders. To investigate pathological mechanisms elicited by perturbed BDNF signaling, we examined mutant mice with central depletion of BDNF (BDNF(2L/2LCk-cre)). A severe impairment specific for the serotonin 2A receptor (5-HT(2A)R) in prefrontal cortex was described previously...
Neurotoxicology
August 26, 2010
MDMA administration decreases serotonin but not N-acetylaspartate in the rat brain.
Neurotoxicity Research
August 2010
Laura Orío, Noemi Llopis, Elisa Torres et al.
3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a selective 5-HT neurotoxin in rat brain which has been shown to produce acute neuroinflammation characterized by activation of microglia and release of interleukin-1beta (IL-1beta). We aimed to determine whether or not minocycline, a semi-synthetic tetracycline antibiotic capable of inhibiting microglial activation, could prevent the...
Psychopharmacology
July 20, 2010
Acute concomitant effects of MDMA binge dosing on extracellular 5-HT, locomotion and body temperature and the long-term effect on novel object discrimination in rats.
European Journal of Pharmacology
July 13, 2010
Role of serotonin and/or norepinephrine in the MDMA-induced increase in extracellular glucose and glycogenolysis in the rat brain.
Journal of Pharmacological Sciences
May 19, 2010
Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures.
Brain
May 17, 2010
Stephen J. Kish, Jason P. Lerch, Yoshiaki Furukawa et al.
170 citations
Animal data indicate that the recreational drug ecstasy (3,4-methylenedioxymethamphetamine) can damage brain serotonin neurons. However, human neuroimaging measurements of serotonin transporter binding, a serotonin neuron marker, remain contradictory, especially regarding brain areas affected; and the possibility that structural brain differences might account for serotonin transporter binding...
Addiction Biology
May 11, 2010
Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.