Known classic psychedelic serotonin 2A receptor (5-HT2AR) agonists retain a tryptamine or phenethylamine at their structural core. However, activation of the 5-HT2AR can be elicited by drugs lacking these fundamental scaffolds. Such is the case of the N-substituted piperazine quipazine. Here, we show that quipazine bound to and activated 5-HT2AR as measured by [3H]ketanserin binding...
Background: In this report, a study protocol for a randomized control trial is presented in an attempt to explore the efficacy of mindfulness-based cognitive therapy (MBCT) for major depressive disorder (MMD), and a case-control study is conducted to find the difference in electroencephalograms (EEGs) between MMD and normal controls. Design: Seventy Chinese patients with MMD will be chosen for...
Background: This was the first randomized controlled trial (RCT) designed to compare the efficacy of mindfulness-based cognitive therapy (MBCT) on unmedicated obsessive-compulsive disorder with that of the first-line treatment for OCD (SSRIs) or a placebo, as well as to analyze the treatment acceptability and safety of MBCT. Methods: A total of 123 unmedicated OCD patients with mild to moderate...
Cannabis can synthetize more than 400 compounds, including terpenes, flavonoids, and more than 100 phytocannabinoids. The main phytocannabinoids are Δ-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Cannabis-based products are used as medicines in several countries. In this text, we present an overview of the main neurochemical mechanisms of action of the phytocannabinoids, especially THC...
La ayahuasca1 es una decocción tradicional amazónica con propiedades psicoactivas, se elabora a partir de la corteza de la vid Banisteriopsis caapi (que contiene alcaloides betacarbolina) y las hojas del arbusto Psychotria viridis (que suministra el alucinógeno N, N-dimetiltriptamina, DMT, que actúa como agonista serotoninérgico 5-HT2A). La ayahuasca se ha incorporado a la medicina popular y la...
Psychedelics are drugs that alter consciousness and affect human psyche. 5-Methoxy- N,N -diisopropyltryptamine (5-MeO-DIPT) emerged in the recreational drug market with the street name “foxy” and has been increasingly used as a substitute for methylenedioxymethamphetamine (MDMA) Methylenedioxymethamphetamine (MDMA) . 5-MeO-DIPT is a competitive inhibitor of the serotonin (5-HT) transporter...
Revista Virtual de Química2021Maria Emanuelle Damazio Lima, Isian Santos da Silva, Mariana de Oliveira Leal Desmarais et al.2 citations
Most of the new developed drugs are natural or analogous products, including those that act on the Central Nervous System. The search for new drugs for the treatment of depression is increasing, in view of the high worldwide incidence of this mental disorder. In this context, tryptophan derivatives have an antidepressant effect due to the presence of indole rings, which give them a similarity...
A dietilamida do ácido lisérgico é uma das substâncias alucinógenas mais potentes já sintetizadas. Sua sigla, LSD, vem do alemão: Lysergsäurediethylamid. O LSD é sintetizado a partir do ácido lisérgico, produzido pelo fungo parasita esporão-do centeio (Claviceps purpurea), nome alusivo ao seu corpo de frutificação e ao principal cereal hospedeiro. O LSD tem afinidade por receptores...
The NBOMe (N-2-methoxybenzyl-phenethylamines) family of compounds are synthetic hallucinogens derived from the 2C series. Although this family of compounds has been responsible for multiple cases of acute toxicity and several deaths around the world, to date there are few studies. These compounds act as potent 5-HT2A receptor agonists, including the hallucinogen 25C-NBOMe...
Psilocybin therapy appears to be at least as effective as escitalopram in treating depression, findings from a small phase II study published in the New England Journal of Medicine have indicated (15 April 2021)[1]. Researchers compared two sessions of psychedelic psilocybin therapy, delivered in a specialist clinical setting, with a course of the selective serotonin […]