Translational Psychiatry
December 5, 2024
Bettina Habelt, Dzmitry Afanasenkau, Cindy Schwarz et al.
6 citations
Patients with alcohol use disorder (AUD) who seek treatment show highly variable outcomes. A precision medicine approach with biomarkers responsive to new treatments is warranted to overcome this limitation. Promising biomarkers relate to prefrontal control mechanisms that are severely disturbed in AUD. This results in reduced inhibitory control of compulsive behavior and, eventually, relapse....
Revista Ibero-Americana de Humanidades, Ciências e Educação
December 4, 2024
Tamyres Cordeiro Leoncio, Danilo Cândido de Araújo Batista
O LSD (dietilamida do ácido lisérgico), tradicionalmente conhecido por seus efeitos psicodélicos, tem atraído crescente interesse na pesquisa científica devido ao seu potencial terapêutico em uma série de distúrbios neurológicos e psiquiátricos. Este artigo revisa as evidências recentes sobre os efeitos do LSD, destacando sua capacidade de promover a neuroplasticidade, modular o sistema...
Translational Psychiatry
December 4, 2024
Kenneth Shinozuka, Katarina Jerotic, Pedro A. M. Mediano et al.
17 citations
Serotonergic psychedelics induce altered states of consciousness and have shown potential for treating a variety of neuropsychiatric disorders, including depression and addiction. Yet their modes of action are not fully understood. Here, we provide a novel, synergistic understanding of psychedelics arising from systematic reviews and meta-analyses of three hierarchical levels of analysis: (1)...
Premier Journal of Science
December 3, 2024
Kanwal Shabir
Background Anxiety disorders are increasingly prevalent among young adults. Traditional treatment options often fall short, and many patients live with treatment-resistant anxiety. Psilocybin is a psychedelic compound that has gained attention for its therapeutic potential against anxiety when used in microdoses. Objective This review aims to evaluate the emerging evidence on psilocybin...
Drug Testing and Analysis
December 3, 2024
Simon D. Brandt, Pierce V. Kavanagh, Sarah Gare et al.
5 citations
The classical psychedelic drug (+)-lysergic acid diethylamide (LSD) continues to attract considerable multidisciplinary interest, and over the last eight decades, many derivatives and analogs of LSD have been synthesized. One site on the ergoline scaffold of LSD that has been frequently modified is the N1-position, with the N1-acylated LSD derivative 1-acetyl-LSD (1A-LSD, ALD-52) being one of...
Regional Anesthesia & Pain Medicine
December 2, 2024
Trent Emerick, Tetyana Marshall, Thomas Jeff Martin et al.
1 citation
Hallucinogen exposure in patients in the perioperative period presents challenges for anesthesiologists and other anesthesia providers. Acute and chronic exposure to these substances can cause physiological impacts that can affect the function of anesthetic and analgesic medications used during perioperative care. The objective of this narrative review is to educate readers on the wide array of...
Alzheimer s & Dementia
December 1, 2024
Jitendra Kumar Sinha, Shampa Ghosh, Krishna Kumar Singh et al.
1 citation
Abstract Background Traditionally associated with recreational and spiritual uses, psychedelics have gained attention in psychotherapy for their therapeutic potential. Functioning as potent 5‐hydroxytryptamine (5HT) agonists, these compounds have demonstrated the ability to enhance neural plasticity by activating serotoninergic and glutamatergic systems. Despite these recognized effects, their...
International Review of Psychiatry
December 1, 2024
Zofia Kozak, Christopher W. T. Miller
7 citations
Psychedelic compounds continue gaining scientific and regulatory traction as potential new treatments for psychiatric disorders. While most psychiatrists will likely not work directly with these compounds, psychedelic research practices provide insights that may improve conventional psychiatric care. Through its emphasis on 'set and setting' (mindset and environment, respectively), psychedelic...
Cureus
December 1, 2024
Ayesha Imtiaz, Bassam M Almutairy, Taghreed M Almutairi et al.
1 citation
Nutmeg and mace are commonly known for their medicinal and culinary properties. The chemical compounds found in nutmeg and mace, notably myristicin, elemicin, and safrole, have been implicated in the psychoactive and anticholinergic effects that are the result of acute toxicity. Cases of mace toxicity are not as commonly reported as nutmeg toxicity. We report a six-year-old child, who presented...
December 1, 2024
Chloe Lily West Jacobs
This dissertation explores the lasting impact of psychedelic use on brain networks, ranging from basic sensory processing to abstract mystical experiences. Recent research has highlighted the potential of these substances for treating psychiatric disorders, with therapeutic effects persisting weeks after a single dose. We focus on serotonergic psychedelics such as psilocybin and LSD, which are...