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Serotonin: all studies

Page 224 of 401: studies 2,231 to 2,240 of 4,004, newest first. Back to the serotonin overview

Research

Synergistic modulation of gut microbiota and mindfulness-based interventions in schizophrenia: Integrating neurotransmitter regulation and multimodal therapeutic strategies

Quality in Sport May 12, 2025 Izabela Zajkowska, Patrycja Niczyporuk, Aleksandra Giba et al. 1 citation

This review explores an innovative, integrative therapeutic approach that combines probiotics, prebiotics, and mindfulness-based interventions (MBIs) to target the dysregulation of the gut–brain axis in schizophrenia. The rationale for this combined strategy is rooted in the overlapping mechanisms by which both biological and psychosocial interventions influence neurophysiological processes....

DOI: 10.12775/qs.2025.41.59834 (opens in new tab) Mindfulness Schizophrenia object-oriented programming Multimodal therapy Psychological intervention +6

Evaluating the Effectiveness of Psychedelic-Assisted Therapy in Treating Alcohol Use Disorders: A Review

Alcoholism Treatment Quarterly May 2, 2025 Ritika Shah, Ashish Sarangi

ABSTRACT Background Alcohol Use Disorder (AUD) is a widespread condition with serious health, social, and economic impacts, often marked by relapse despite the availability of FDA-approved treatments. Recent studies suggest that psychedelic substances, such as psilocybin, Lysergic acid diethylamide (LSD), ayahuasca, etc. may offer novel therapeutic potential in treating AUD by modulating...

DOI: 10.1080/07347324.2025.2500345 (opens in new tab)

The effect of esketamine on postoperative anxiety and depression in patients with thyroid cancer: A randomized, double-blind, placebo-controlled, parallel-group trial.

Medicine May 2, 2025 Xiaobo Bi, Junchao Dai, Jin Li 8 citations

This study aimed to investigate the effects of a single intravenous injection of esketamine during general anesthesia on postoperative anxiety and depression in patients with thyroid cancer. In this randomized, double-blind, placebo-controlled, parallel-group trial, eighty female patients with thyroid cancer were scheduled to undergo surgery under general anesthesia. The patients were randomly...

DOI: 10.1097/MD.0000000000042284 (opens in new tab) Full text (opens in new tab) Affective symptoms Postoperative complication Thyroid cancer surgery Esketamine therapy +3

The effect of medial prefrontal cortex inactivation on psychedelic-mediated emergence from anesthesia

Physiology May 1, 2025 Andres Villegas Calderon, Emma R. Huels, Amanda Nelson et al.

Serotonergic psychedelics are being explored as therapeutic agents for mental health disorders and have also been shown to promote wakefulness. In a recently completed study (reported as preliminary findings), we showed that intravenous administration of 2,5-Dimethoxy-4-iodoamphetamine (DOI), a classic serotonergic psychedelic, can induce wakefulness and reverse the state of anesthesia produced...

DOI: 10.1152/physiol.2025.40.s1.0127 (opens in new tab)

Psilocybin

May 1, 2025 Jessi Humphreys, Lou Lukas, Yvan Beaussant et al.

Abstract Psilocybin, a naturally occurring psychoactive compound found in more than 200 mushroom species, has an enduring history of use in sacred rituals of Indigenous healers worldwide. With selective serotonin receptor binding, activation of the serotonergic neurological system enables psilocybin to potentiate neuroplasticity, enabling individuals to engage in meaning-making from psychedelic...

DOI: 10.1093/med/9780197760864.003.0002 (opens in new tab) Psilocybin Hallucinogen

Understanding and treating postpartum depression: a narrative review.

International Clinical Psychopharmacology May 1, 2025 Vincenzo Cardaci, Matteo Carminati, Mattia Tondello et al. 7 citations

Postpartum depression (PPD) is an increasingly prevalent but still poorly characterized disorder. Causal and modulating factors include hormones fluctuations, such as estrogen, progesterone, and allopregnolone, pathways imbalances, such as oxytocin and kynurenine, chronobiological factors, and brain imaging alterations. Treatment may differ from the traditional major depression management,...

DOI: 10.1097/YIC.0000000000000560 (opens in new tab) Full text (opens in new tab) Postpartum depression ppd Postnatal depression Maternal wellness Behavioral therapy +2

Ketamine in insulin resistance: Pharmacokinetics, cardiovascular implications and cellular effects on cardiomyocytes.

Diabetes, Obesity & Metabolism May 1, 2025 Ariana Ramirez, Stephanie Howes, Robert Chilton 3 citations

Ketamine, a dissociative anaesthetic, has expanded its clinical use beyond anaesthesia to pain management and treatment-resistant depression. As an N-methyl-d-aspartate receptor antagonist, ketamine disrupts the excitatory neurotransmission via interaction with the opioid, alpha-amino-3-hydroxy-5-methyl-4-isooxazole-propionic acid receptor and serotonin pathways, contributing to its broad...

DOI: 10.1111/dom.16248 (opens in new tab) Full text (opens in new tab) Cardiovascular disease Diabetes complications Drug mechanism Insulin resistance +5

Safety in treatment: Classical pharmacotherapeutics and new avenues for addressing maternal depression and anxiety during pregnancy.

Pharmacological Reviews May 1, 2025 Merel Dagher, Catherine M Cahill, Anne M. Andrews 10 citations

We aimed to review clinical research on the safety profiles of antidepressant drugs and associations with maternal depression and neonatal outcomes. We focused on neuroendocrine changes during pregnancy and their effects on antidepressant pharmacokinetics. Pregnancy-induced alterations in drug disposition and metabolism impacting mothers and their fetuses are discussed. We considered evidence...

DOI: 10.1016/j.pharmr.2025.100046 (opens in new tab) Full text (opens in new tab) Mental health Pregnancy Antidepressants Maternal depression +1

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine-Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms.

Advanced Science May 1, 2025 Yuanpeng Li, Hongyuan Li, Hongshuang Wang et al. 3 citations

The surge of new psychoactive substances (NPS) poses significant public health challenges due to their unregulated status and diverse effects. However, existing in vivo models for evaluating their activities are limited. To address this gap, this study utilizes the model organism Caenorhabditis elegans (C. elegans) to evaluate the activity of amphetamine-type stimulants (ATS) and their analogs....

DOI: 10.1002/advs.202500808 (opens in new tab) Full text (opens in new tab) Behavioral testing Pharmacology Amphetamine‐type stimulants New psychoactive substances +4