Los hongos que contienen psilocibina han sido utilizados durante siglos por culturas mesoamericanas en rituales sagrados, donde se consideraban un puente hacia lo divino. En la actualidad, esta sustancia ha captado el interés de la ciencia moderna. Cuando se consume, la psilocibina se transforma en psilocina, su forma activa, que actúa principalmente sobre receptores de serotonina en el...
21 Feasibility of a Multicomponent Protocol to Promote Dreaming during Surgical AnesthesiaImage: A. Johnson, Vivo Visuals Studio.Implementation of a treatment bundle consisting of verbal priming, propofol infusion, electroencephalography-guided titration, 10 min or longer of minimization of stimulation, and immediate dream interviews resulted in a high incidence of reported dreaming. Apart from...
Abstract Brain dynamics can be described in three different convenient mathematical languages, namely connectome harmonics, turbulence and complex harmonics (CHARM). Here we demonstrate that these theoretical frameworks can be rigorously unified, under the functional calculus, as one self-adjoint operator and its single spectral measure. The connectome Laplacian carries that measure; the...
Abstract Background . It is widely accepted that beyond the pharmacological predictors, individuals’ pre-drug mental disposition, including intentions , influences the psychedelic experience. However, is it not fully clear how intentions and outcomes relate. This study explores the intention qualities beyond classically assessed category and explicitness in association with outcomes. Methods ....
Chronic pain is common, costly, and for many, remains inadequately treated by existing pharmacologic and non-pharmacologic approaches. In parallel with growing dissatisfaction with conventional therapies, classic serotonergic psychedelics, such as psilocybin, lysergic acid diethylamide (LSD), ayahuasca, N,N-dimethyltryptamine (DMT), and mescaline, administered alone or within...
Background: Traumatic brain injury (TBI) can result in prolonged post-concussive syndrome and chronic hypoxic-ischemic brain injury (HIBI) sequelae remains therapeutically challenging with the persistence of significant neurological and cognitive impairments. While conventional treatments often provide limited relief, emerging research explores alternative therapeutic interventions, including...
A ibogaína é um alcaloide indólico extraído da Tabernanthe iboga, investigado por seu possível papel na redução de sintomas de abstinência, fissura e recaída em transtornos por uso de substâncias. Este estudo teve como objetivo analisar, por meio de revisão de literatura, as evidências científicas sobre eficácia, segurança, mecanismos farmacológicos e implicações ético-regulatórias do uso da...
Classical serotonergic psychedelics, such as psilocybin, show emerging evidence of therapeutic potential across a range of mental health disorders, including depression, anxiety, and substance use disorders, with indications of transdiagnostic efficacy. While early-phase studies yielded encouraging results, recent larger-scale phase 3 trials, such as those evaluating psilocybin for...
Introduction MM120 (lysergide D-tartrate, LSD, CAS 32426-57-6) is under development as a potential treatment for generalized anxiety disorder and major depressive disorder. MM120 may elicit profound lasting psychological changes through interaction with brain 5-HT1A, 1B, 2A, 2C, 6 and 7 receptors, among others, while the complete mechanism is not clear. Objectives The study was performed to...
European PsychiatryJune 1, 2026P. Argitis, M. Demetriou, T. Koukouras et al.
Introduction Intravenous (IV) ketamine has demonstrated rapid antidepressant and anti-suicidal effects in treatment-resistant depression (TRD), yet interindividual variability in response remains significant. One unexplored factor is the impact of concomitant antidepressant medication during ketamine treatment. Desvenlafaxine, a serotonin-norepinephrine reuptake inhibitor (SNRI), may enhance...