Neuropharmacology
2009
Massimo Grilli, Elisa Neri, Stefania Zappettini et al.
We investigated the effects of salvinorin A on the basal and the 12 mM K(+)-evoked release of preloaded [(3)H]noradenaline ([(3)H]NA) and [(3)H]serotonin ([(3)H]5-HT) from mouse hippocampal nerve terminals (synaptosomes), as well as on the basal and 12mM K(+)-evoked release of preloaded [(3)H]dopamine ([(3)H]DA) from mouse striatal and prefrontal cortex (PFc) synaptosomes. Salvinorin A...
Journal of Synthetic Organic Chemistry Japan
2009
Hisahiro Hagiwara, Masato Nozawa
2 citations
Total synthesis of salvinorin A (1), a densely functionalized neoclerodane diterpenoid, having the most potent hallucinogenic activity and a selective κ–opioid agonist, has been completed in 20 steps starting from enantiomerically–pure Wieland–Miescher ketone derivative 23. Subsequently, alternative total synthesis of salvinorin A (1) has been developed via palladium–catalyzed double...
Molecular imaging and biology
2009
Jacob M Hooker, Vinal Patel, Shiva Kothari et al.
Salvinorin A (SA) is a potent and highly selective kappa-opioid receptor (KOR) agonist with rapid kinetics and commensurate behavioral effects; however, brain regions associated with these effects have not been determined. Freely moving adult male rats were given SA intraperitoneally during uptake and trapping of the brain metabolic radiotracer, 2-deoxy-2-[F-18]fluoro-D: -glucose (FDG),...
Neuroscience Letters
December 3, 2008
Pieter Beerepoot, Vincent M Lam, Alice Luu et al.
Locomotor sensitization induced by the dopamine agonist quinpirole can be potentiated by co-treatment with the synthetic kappa opioid agonist U69593. The identification of salvinorin A, an active component of the psychotropic sage Salvia divinorum, as a structurally different agonist of kappa-opioid receptors raised the question of whether this compound would similarly potentiate sensitization...
British Journal of Pharmacology
November 1, 2008
Raffaele Capasso, Francesca Borrelli, M G Cascio et al.
82 citations
Salvinorin A, the active component of the hallucinogenic herb Salvia divinorum, inhibits intestinal motility through activation of kappa-opioid receptors (KORs). However, this compound may have target(s) other than the KORs in the inflamed gut. Because intestinal inflammation upregulates cannabinoid receptors and endogenous cannabinoids, in the present study we investigated the possible...
Neuropsychopharmacology
October 2008
Elena H Chartoff, David Potter, Diane Damez-Werno et al.
Stress and chronic exposure to drugs of abuse can trigger addictive and depressive disorders. Both stimuli increase activity of dynorphin, a neuropeptide that acts at kappa-opioid receptors (KORs). In humans, KOR agonists cause dysphoria, raising the possibility that dynorphin modulates the depressive-like effects of stress and chronic drug use. We examined if KOR activation alters sensitivity...
The Journal of Clinical Psychiatry
September 30, 2008
Michael Paulzen, Gerhard Gründer
32 citations
Article AbstractBecause this piece has no abstract, we have provided for your benefit the first 3 sentences of the full text. Sir: The hallucinogenic sage Salvia divinorum (S.divinorum) is known by many names, including ska Maria, skaPastora, hojas de Maria, and many others. Despite its manynames, S. divinorum was not identified until 1962, whenWasson and Hofmann collected a member of the...
ChemInform
September 16, 2008
Thomas E Prisinzano, Richard B Rothman
Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Journal of Drug Education
September 1, 2008
David N Khey, Bryan Lee Miller, O. Hayden Griffin
45 citations
The recreational use of Salvia divinorum has received increased attention by media outlets and policy-makers in recent years. The vast absence of research to guide the dissemination of information has prompted this research note describing the use of this substance in a large public institution of higher education. The prevalence of Salvia divinorum is described in this context and a...
ChemInform
August 26, 2008
Masato Nozawa, Yuhki Suka, Takashi Hoshi et al.
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.