Psychopharmacology
April 1, 2011
John Mendelson, Jeremy Coyle, Juan Carlos Lopez et al.
40 citations
Salvinorin A (SA) is a highly selective kappa opioid receptor agonist and the putative psychoactive compound in Salvia divinorum (SD), an increasingly abused hallucinogenic plant. The objectives of this study were to characterize the physiological and subjective effects of SA versus placebo and measure drug and metabolite levels. Sublingual SA doses up to 4 mg were administered in dimethyl...
Substance Abuse and Rehabilitation
April 1, 2011
Li-Tzy Wu, George E Woody, Chongming Yang et al.
40 citations
CONTEXT: Media and scientific reports have indicated an increase in recreational use of Salvia divinorum. Epidemiological data are lacking on the trends, prevalence, and correlates of S. divinorum use in large representative samples, as well as the extent of substance use and mental health problems among S. divinorum users. OBJECTIVE: To examine the national trend in prevalence of S. divinorum...
Bioorganic & Medicinal Chemistry Letters
January 1, 2011
Jakub Fichna, Kevin Lewellyn, Feng Yan et al.
The synthesis and in vitro evaluation of a new series of salvinorin A analogues substituted at the C(2) position with natural amino acids is reported. Compound 12, containing Val, displayed high affinity and full agonist activity at the kappa-opioid receptor. Analogues with bulky and/or aromatic residues were inactive, showing the importance of size and electronegativity of C(2)-substituents...
Farmacognosia
2011
F. Capasso
Gli allucinogeni sono sostanze psicoattive capaci di causare ‘sostanziali e transitorie modificazioni della percezione, del pensiero e dell’umore’. Possono essere classificate in base al loro meccanismo d‘azione oppure in base alla loro struttura chimica.
Journal of Psychoactive Drugs
2011
Brian C Kelly
39 citations
During recent years, there has been increasing interest in "legal highs" among youth and young adults. Salvia divinorum is a legally available hallucinogenic plant, primarily utilized in smokable form, that produces a brief but intense hallucinogenic experience for the user. Data are presented from an ethnographic project to provide a qualitative profile of salvia use among young adults. Most...
Pharmacological Reports
2011
Joanna Listos, Alicja Merska, Sylwia Fidecka
52 citations
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been historically used for divination and shamanism by the Mazatecs. Today, S. divinorum has become increasingly popular as a recreational drug for its hallucinogenic effects. The non-nitrogenous diterpene, salvinorin A, the major active component of S. divinorum, is responsible for the...
Bioorganic & Medicinal Chemistry Letters
October 1, 2010
David Y W Lee, Lu Yang, Wei Xu et al.
Salvinorin A (1), the main active ingredient of Salvia divinorum, is a potent and selective κ opioid receptor (KOPR) agonist. Based on the SAR, its C-2 position is one of the key binding sites and has very little space tolerance (3-4 carbons atoms) and limited to only lipophilic groups. In our attempt to prepare PET brain imaging agent for mapping KOPR, a series of C-2 halogenated analogs have...
Drug and Alcohol Dependence
October 1, 2010
Matthew J. Baggott, Earth Erowid, Fire Erowid et al.
78 citations
There is growing use of Salvia divinorum (SD), a psychoactive plant that produces hallucinogen-like effects through a kappa opioid receptor (KOR) mechanism. Little is known about KOR agonist effects in humans and about users of SD. To characterize the reasons, methods, and reported consequences of SD use. Individuals reading SD-related pages of a drug-information website were invited to...
Tetrahedron Letters
September 29, 2010
Zhongze Ma, Gang Deng, David Y W Lee
11 citations
Salvinorin A is a naturally-occurring potent and selective kappa opioid receptor agonist, and smoking salvinorin A produces the most intense hallucinogenic effects in human. Eight neoclerodane diterpene derivatives were isolated from the smoke of salvinorin A, and their structures were identified by spectroscopic methods. The major structural changes include epimerizations, eliminations, and...
Planta Medica
September 1, 2010
Stephen M Phipps, Veronika Butterweck
The compulsive gnawing (CG) test has been used for numerous years as an assay to determine the dopaminergic activity of various compounds. We developed a new method of quantification via a digitization step which allowed a more precise measurement of the gnawing activity. It was the aim of the present study to explore possible dopaminergic effects of salvinorin A (SA), the major active compound...