Psychedelic Medicine
June 1, 2026
William E Rosa, Stephanie Napolitano, Natalie Mcandrew et al.
Psilocybin shows encouraging outcomes for patients with cancer and major depressive disorder (MDD). However, there is insufficient evidence on the use of evidence-based psychotherapeutic interventions to consistently guide and standardize psilocybin preparation, dosing, and integration. Meaning-centered psychotherapy (MCP) is a manualized, brief psychotherapeutic intervention that enhances...
Journal of Psychoactive Drugs
May 22, 2026
Fiona Low, Mitch Earleywine
Limited research suggests that distinct intentions covary with acute experiences and subsequent outcomes. Nevertheless, data on the types of intentions set by users remain scarce, and their effects lack clarity. This study uses a retrospective, mixed-methods, cross-sectional approach to investigate intention-setting among psychedelic users. We establish a taxonomy of intentions in naturalistic...
Current Topics in Medicinal Chemistry
May 21, 2026
Guizhen Lyu, Dongbing Li
Depression is a leading cause of global disability, affecting over 300 million individuals and imposing substantial personal, clinical, and societal burdens. This comprehensive review synthesizes recent advances in understanding depression across biological, cognitive, and psychosocial domains, emphasizing innovations in diagnosis, pathophysiology, and treatment. We explore emerging...
BMC Medicine
May 19, 2026
Rebecca Morris, Ayse Gundogan, Vanessa Lawrence et al.
Eating disorders (EDs) have complex presentations with high rates of comorbidities and low recovery rates. Current treatment options often lack sufficiency in improving ED symptoms. Psychedelic-assisted therapies represent a novel treatment approach for the treatment of EDs, with research documenting preliminary positive evidence. However, psychedelics have their own challenges and risks which...
Current Psychiatry Reports
May 14, 2026
Jamarie Geller, Rachel M Pacilio, Amanda E. Downey et al.
There is growing evidence that psychedelics and associated treatment modalities may offer therapeutic benefits across a range of psychiatric conditions. Anorexia nervosa (AN), a serious and often treatment-resistant illness associated with significant morbidity and mortality, is one such condition for which psilocybin-assisted therapy (PAT) may hold promise. To date, research on PAT for AN has...
Trends in Psychiatry and Psychotherapy
April 25, 2026
Alberto Barbieri
Personality disorders (PDs) are characterized by rigid and maladaptive patterns of self- and interpersonal functioning, leading to high clinical burden and limited treatment outcomes. Schema Therapy (ST), an integrative psychotherapy rooted in cognitive-behavioral principles, conceptualizes PDs in terms of Early Maladaptive Schemas (EMS)-pervasive cognitive-affective structures formed through...
Journal of Psychoactive Drugs
April 23, 2026
Brayan Jonas Mano-Sousa, Maria Clara Gama Fontes, Ana Clara Anacleto Gonçalves et al.
Suicide, particularly in treatment-resistant depression (TRD), remains a pressing global health issue, with over 700,000 annual deaths. Existing treatments often have limited efficacy and delayed onset, creating a need for rapid-acting interventions. Ayahuasca, a traditional Amazonian psychedelic, has shown potential for rapidly reducing suicidal ideation. Our systematic review evaluated the...
Journal of Indian Association of Public Health Dentistry
April 6, 2026
Chetan Vinay Deshmukh, Vibhuti Dilip Mistry, Prakash Maruti Kasbe et al.
Nicotine addiction is a major contributor to preventable morbidity and mortality globally, forming the biological basis of the tobacco pandemic. Despite the availability of nicotine replacement therapies and behavioral interventions, relapse rates remain high due to nicotine’s profound impact on neurochemical reward pathways. To explore and review novel and emerging treatment modalities that...
Journal of Affective Disorders
February 15, 2026
Tomas Lindegaard, Anton Käll
Although there is increasing evidence of the efficacy of psychedelic-assisted psychotherapy (PAP) for depressive and anxiety disorders, less is known regarding how different methodological aspects affect outcomes. This study investigated the moderating impact of one or multiple dosing sessions and type of adjunctive psychotherapy on the efficacy of PAP in depression and anxiety populations....
Indian Journal of Psychological Medicine
February 5, 2026
Ashlyn Tom, B. Sai Chaitanya Reddy, Manik Inder Singh Sethi et al.
The “entourage effect,” well-documented in cannabis research, remains a hypothesis requiring validation in psilocybin mushrooms. Whether the complex interplay among multiple bioactive compounds (including psilocybin, psilocin, baeocystin, norbaeocystin, aeruginascin, and various alkaloids) produces synergistic effects distinct from those of isolated psilocybin remains a critical empirical...