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Routledge eBooks June 14, 2018 A. C. Parrott 7 citations
This chapter aims to critically evaluate methamphetamine derivative (MDMA) proposal from a psychobiological perspective. It overviews the early years of MDMA-assisted psychotherapy up to 1986, when MDMA was scheduled as a Class A drug. The chapter also reviews the psychobiology of MDMA, focusing on its diverse mood effects, while also covering other psychobiological functions. It presents a...
Progress in Neuro-Psychopharmacology and Biological Psychiatry June 8, 2018 Allison A. Feduccia, Michael C Mithoefer 213 citations
MDMA-assisted psychotherapy for treatment of PTSD has recently progressed to Phase 3 clinical trials and received Breakthrough Therapy designation by the FDA. MDMA used as an adjunct during psychotherapy sessions has demonstrated effectiveness and acceptable safety in reducing PTSD symptoms in Phase 2 trials, with durable remission of PTSD diagnosis in 68% of participants. The underlying...
The Lancet Psychiatry June 1, 2018 A. Cipriani, P. Cowen
Published online at: https://doi.org/10.1016/S2215-0366(18)30170-6 Eligible users can access the full text via NHS OpenAthens at [https://www.clinicalkey.com/#!/content/journal/1-s2.0-S2215036618301706] (login required).
Journal of Psychedelic Studies May 30, 2018 Peter Eischens, William Leigh Atherton
Background: Traditional treatment interventions for alcohol use disorders (AUD) have produced mixed outcomes and the global increase in AUDs demands novel and innovative approaches to addiction treatment.Psychedelic substances have been reintroduced into the Western medical community as a potential intervention to complement the treatment of AUDs.Objectives: This paper will discuss the...
The Lancet Psychiatry May 1, 2018 Michael C Mithoefer, Ann T Mithoefer, Allison A. Feduccia et al. 443 citations
Background: Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first responders, many of whom do not respond to currently available treatments. This study aimed to assess the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for treating chronic PTSD in this population. Methods: We did a randomised, double-blind, dose-response,...
Psychopharmacology May 1, 2018 Mendel Kaelen, Bruna Giribaldi, Jordan Raine et al. 9 citations correction
The article The hidden therapist: evidence for a central role of music in psychedelic therapy, written by Mendel Kaelen, Bruna Giribaldi, Jordan Raine, Lisa Evans, Christopher Timmerman, Natalie Rodriguez, Leor Roseman, Amanda Feilding, David Nutt, Robin Carhart-Harris, was originally published electronically on the publisher's internet portal.
Adaptive Behavior April 4, 2018 Tom Froese, Iwin Leenen, Tomáš Páleníček 8 citations
After a hiatus of several decades, there has been a resurgence of studies into the therapeutic potential of serotonergic psychedelics. When administered in controlled settings, they have been reported to induce a wide variety of long-lasting positive psychological changes. However, the mechanisms by which psychedelics impart these long-lasting benefits remain poorly understood. Here, we...
Frontiers in Pharmacology April 3, 2018 Tara C. Malone, Sarah E. Mennenga, Jeffrey Guss et al. 128 citations
A growing body of evidence shows that existential and spiritual well-being in cancer patients is associated with better medical outcomes, improved quality of life, and serves as a buffer against depression, hopelessness, and desire for hastened death. Historical and recent research suggests a role for psilocybin-assisted psychotherapy in treating cancer-related anxiety and depression. A...
Frontiers in Neuroscience March 6, 2018 Ido Hartogsohn
Past research has demonstrated to the ability of psychedelics to enhance suggestibility, and pointed to their ability to amplify perception of meaning. This paper examines the existing evidence for the meaning-enhancing properties of psychedelics, and argues that the tendency of these agents to enhance the perception of significance offers valuable clues to explaining their reported ability to...
Frontiers in Pharmacology February 20, 2018 Michael P. Bogenschutz, Samantha K. Podrebarac, Jessie H. Duane et al. 125 citations
After a hiatus of some 40 years, clinical research has resumed on the use of classic hallucinogens to treat addiction. Following completion of a small open-label feasibility study, we are currently conducting a double-blind placebo-controlled clinical trial of psilocybin-assisted treatment of alcohol use disorder. Although treatment effects cannot be analyzed until the study is complete,...