Sleep disturbances (SDs) are among the most distressing and commonly reported symptoms in posttraumatic stress disorder (PTSD). Despite increased attention on sleep in clinical PTSD research, SDs remain difficult to treat. In Phase 2 trials, 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy has been shown to greatly improve PTSD symptoms. We hypothesized that MDMA-assisted...
‘The phenomenology of psychedelic therapy’ provides a selective overview of experiences commonly reported by those who take psychedelics in controlled and structured settings, such as clinical trials and religious rituals. The first half of this chapter reviews a variety of typical changes to perception and the sense of self. The second half reviews qualitative evidence concerning patients’...
‘The mechanisms of psychedelic therapy’ presents arguments against three theories of psychedelic therapy. The Molecular Neuroplasticity Theory ascribes therapeutic benefits to an experience-independent molecular mechanism. This theory is undermined by the correlation between ‘mystical-type experiences’ and beneficial outcomes, which suggests that genuinely psychological mechanisms are involved....
Background: In controlled, clinical studies of the impact of psilocybin on patients with life-threatening cancers, Johns Hopkins and NYU researchers found that the “intensity of the mystical experience” induced by psychedelic-assisted psychotherapy was directly correlated with the alleviation of cancer-related mental distress. Objective: The purpose of this article is to explore the proposition...
This systematized review found important commonalities among clinical trials of PAP published within the past 25 years and revealed key differences among studies in psychotherapy's incorporation into PAP. Additional research is needed to identify the unique effect of psychotherapy in PAP.
Positive findings from a phase 3 trial may have brought MDMA-assisted therapy closer to FDA approval, but experts remain unclear about how long the effects of the therapy might last. When Charles Raison, M. D. , a professor of psychiatry and the Mary Sue and Mike Shannon Chair for Healthy Minds, Children & Families at the University of Wisconsin-Madison joined the scientific board at the...
Addressing global mental health is a major 21st-century challenge. Current treatments have recognized limitations; in this context, new ones that are prophylactic and effective across diagnostic boundaries would represent a major advance. The view that there exists a core of transdiagnostic overlap between psychiatric disorders has re-emerged in recent years, and evidence that psychedelic...
The present narrative review is the first in a series of reviews about the appropriate conduct in substance-assisted psychotherapy (SAPT). It outlines a current perspective onpreconditions and theoretical knowledge that have been identified as valuable in the literaturefor appropriate therapeutic conduct in SAPT. In this context, considerations regarding ethics and the spiritual emphasis of the...
I’ve always been drawn to specialties where medicine can be practised holistically. It’s one of the reasons I applied for GP training and am currently undertaking a diploma in lifestyle medicine. My last post as a second-year GP trainee was a 6-month placement in palliative medicine at a well-known inner London hospice. While on this rotation, I came across patients who suffered with ‘total...
Two systematic reviews, 3 randomized controlled trials, and 2 single-arm safety trials were identified that evaluated several combinations of psychedelic-assisted psychotherapy. Psilocybin was the psychedelic most tested. Other psychedelics identified in the systematic reviews and primary studies were 3,4-methylenedioxymethamphetamine (or MDMA), lysergic acid diethylamide (or LSD), ayahuasca...