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Oxford University Press eBooks August 1, 2021 Chris Letheby
Philosophy of Psychedelics is the first scholarly monograph in English devoted to the philosophical analysis of psychedelic drugs. Its central focus is the apparent conflict between the growing use of psychedelics in psychiatry and the philosophical worldview of naturalism, which holds that the natural world is all that exists. The book reviews scientific evidence that psychedelics such as...
Philosophy of Psychedelics August 1, 2021 Chris Letheby 1 citation
‘On the need for a natural philosophy of psychedelics’ provides a brief overview of the history of psychedelics in science and psychiatry, and a detailed review of recent evidence for their therapeutic and transformative efficacy. The chapter reviews clinical trials showing that one or two controlled psychedelic experiences can durably reduce symptoms of anxiety, depression, and addiction, and...
Research, Society and Development July 31, 2021 Henrique da Cunha Santos, Cássio Ilan Soares Medeiros
Objetivo: O presente estudo é uma abordagem geral sobre a ciência psicodélica e tem por objetivo, a partir de uma revisão integrativa da literatura, contextualizar o renascimento da terapia psicodélica. Metodologia: Por meio da pesquisa na base de dados eletrônica Medical Publications (PubMed) e na Scientific Eletronic Library (Scielo) com o descritor em inglês: "psychedelic therapy" foram...
Life July 29, 2021 Dominika Psiuk, Emilia Nowak, Krystian Cholewa et al. 13 citations
Due to an increasing number of depression diagnoses and limited effective treatments, researchers continue to explore novel therapeutic strategies for this disorder. Recently, interest has revolved around the use of serotonergic psychedelics to reduce the symptoms of depression. In this systematic review, we summarize the currently available knowledge on the safety and efficacy of psychedelic...
Journal of Humanistic Psychology July 20, 2021 Mariavittoria Mangini 2 citations
The drug experiences of women in Western society have been both sensationalized for their scandalous aspects and sterilized in clinical reports, but the role of women in the investigation of psychedelics in modern Western history is obscure, and the identities and activities of early women participants are often unknown. This paper explores some of the under-reported history of women’s...
Frontiers in Pharmacology July 13, 2021 Friederike Holze, Isidora Avedisian, Nimmy Varghese et al. 66 citations
The psychedelic lysergic acid diethylamide (LSD) has experienced a revival in research, including clinical trials that evaluate LSD-assisted psychotherapy. LSD induces perceptual alterations and influences emotion processing in ways that may support psychotherapy. Here, we investigated the effects of LSD on emotional empathy and mediating role of the serotonin 5-hydroxytryptamine-2A (5-HT 2A )...
Psychopharmacology July 12, 2021 Benjamin Malcolm, Kelan Thomas 131 citations
RationaleIn recent years, psychedelic substances with serotonergic mechanisms have accumulated substantial evidence that they may provide therapeutic benefits for people suffering with psychiatric symptoms. Psychiatric disorders targeted by these psychedelic-assisted therapies are managed with serotonergic drugs like selective serotonin reuptake inhibitors (SSRIs) as the current standard of...
Chronic Stress July 11, 2021 C. Healy, K. A. Lee, Wendy D’andrea 39 citations
Background Child maltreatment negatively affects the formation of internal schemata of self and other during development, leading to negative adaptations in self-concept and social cognition. Clinical reports suggest the efficacy of psychedelics in treating the psychopathological sequelae of child maltreatment. Altering maladaptive schemata of self and other implicated in negative self-concept...
PsyArXiv July 8, 2021 Chris Letheby preprint
In this précis I summarise the main ideas of my book Philosophy of Psychedelics . The book discusses philosophical issues arising from the therapeutic use of classic psychedelic drugs such as psilocybin and LSD. The book is organised around what I call the Comforting Delusion Objection to psychedelic therapy: the concern that this novel and promising treatment relies essentially on the...
Expert Review of Clinical Pharmacology July 6, 2021 E. Schenberg
Dear Editors, Unblinding is an important confounding in pharmacological research potentially affecting rigor and objectivity of the scientific data underlying evidence-based medicine. Therefore, I want to commend the work by Muthukumaraswamy et al. [1] reporting on this problem in clinical trials with psychedelics (Ketamine, LSD, psilocybin and ayahuasca), which are rapidly becoming a focus of...