This manuscript comprehensively reviews psilocybin-assisted therapy for major depressive disorder and treatment-resistant depression. It aims to synthesize current understanding regarding its mechanisms, efficacy, safety, costs, and accessibility, comparing it with conventional antidepressant and ketamine treatments. The methodology involved a narrative synthesis of academic literature, drawing...
Abstract A recurring finding in psychedelic-assisted therapy is that the subjective intensity and quality of the psychedelic experience contribute more to therapeutic outcomes than the administered dose. To explain why such experiences are therapeutic, many have appealed to what these may reveal or enable, such as the types of mental representations that can be acquired, the expansion of what...
Psychedelic-assisted psychotherapy is gaining recognition as a novel approach in mental health care, with the potential to support emotional processing, self-understanding, and personal growth. Early evidence suggests that psychedelic-assisted therapies can catalyze transformative experiences that traditional interventions may not access. This article explores the ethical considerations of...
The postpartum period is notorious for rapid and profound changes for birthing individuals and their families. Significant shifts to hormonal and physical health, routines and family roles, and the salience of personal and community risk factors all contribute to potential psychiatric and psychological distress for parents, sometimes diagnosed as a postpartum mood or anxiety disorder (PMAD)....
The original MAPS manual for MDMA-assisted therapy (MDMA-AT) opened a therapeutic frontier for PTSD. However, it drew critique for concepts—such as “inner healing intelligence” – that originated in transpersonal traditions rather than academic or empirically grounded clinical models. While many patients found the therapies helpful, these constructs were difficult to interpret and standardize....
JAMA Network OpenJanuary 2, 2026Gianluca Andri Florineth, Isabell Klima, Anna Laura Boeker et al.5 citations
Psychedelic-assisted therapy (PAT) is a novel intervention for depressive symptoms, typically delivered with additional psychological therapy sessions. Quantitative evidence on how this concomitant therapy contributes to treatment outcomes is limited, highlighting the need for a systematic synthesis. To evaluate whether the quantity of psychological therapy is associated with symptom reduction...
This project documents the early days of establishing safe and ethical psychedelic-assisted therapy services in the Yukon, Canada, in the absence of a territorial, regulatory framework. Grounded in an Indigenous relational epistemology and a Celtic pagan animist worldview, the author draws on ethnobiographical narrative to account for the educational, relational, and advocacy work undertaken in...
Introduction Psychedelic assisted therapy has gained increasing clinical and research attention in the last decade due to its demonstrated therapeutic potential across a variety of complex and treatment-resistant psychiatric and psychosocial conditions. As interest grows, so has the development of facilitator education and training programs. Despite this proliferation, concerns remain regarding...
2026Marija Pranjić, Lia Pikus, Eliza Banbury
preprint
The rapid expansion of psychedelic research over the past decade reflects a convergence of regulatory easing, replicated evidence for clinical efficacy, and advances in modern neuroscience methods. Within this context, music—long treated as a contextual element of “set and setting”—has increasingly been reframed as an active modulator of emotional, cognitive, and neural processes during...
This dissertation presents three interlocking empirical studies united by a single dynamical systems framework: that behavioral flexibility depends on the moment-to-moment timing of frontal cortical state transitions by a reciprocally coupled subcortical circuit, and that this timing mechanism can be pathologically disrupted or pharmacologically restored.