These aren’t the beliefs you’re looking for: on the limits of affect-neutral accounts of psychedelic therapy
Celia R. Blaise
Synthese January 26, 2026 DOI: 10.1007/s11229-026-05443-x (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Keywords | Philosophy of science Philosophy of language Distress Metaphysics Phenomenon Quality philosophy Therapeutic relationship Epistemology Psychotherapist Cognitive psychology Character mathematics |
| Key points | Argues that belief disruption or expanded awareness alone cannot explain the therapeutic benefits of psychedelic experiences without a positive shift in affective valence. |
Abstract
Abstract A recurring finding in psychedelic-assisted therapy is that the subjective intensity and quality of the psychedelic experience contribute more to therapeutic outcomes than the administered dose. To explain why such experiences are therapeutic, many have appealed to what these may reveal or enable, such as the types of mental representations that can be acquired, the expansion of what can enter awareness, or the revision of high-level beliefs about the self and the world. Across these proposals, some form of belief disruption is often assigned a causal role. In this paper, I argue that even if psychedelics do work by loosening beliefs or expanding awareness, this alone is not sufficient to explain why the resulting changes should be beneficial rather than neutral or harmful. By implicitly taking for granted the typically positive character of many psychedelic experiences, existing theories risk describing processes that could just as easily worsen distress as alleviate it, and so fail to reflect the literature’s predominantly positive outcomes. Ultimately, I argue that without a positive shift in affective valence, there is no clear reason why psychedelic experiences should lead to therapeutic outcomes.
Comparable studies
Other theoretical and historical papers on psychedelic-assisted therapy, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Theorizing that Psychedelic Assisted Therapy May Play a Role in the Treatment of Trauma-Induced Personality Disorders. | 2024 | Theoretical or philosophical paper | |
| Learning to Let Go: A Cognitive-Behavioral Model of How Psychedelic Therapy Promotes Acceptance | 2020 | Theoretical or philosophical paper | |
| Awe: a putative mechanism underlying the effects of classic psychedelic-assisted psychotherapy | 2018 | Theoretical or philosophical paper | |
| Ethical and legal issues in psychedelic harm reduction and integration therapy | 2021 | Theoretical or philosophical paper | |
| Towards psychedelic apprenticeship: Developing a gentle touch for the mediation and validation of psychedelic-induced insights and revelations. | 2022 | Theoretical or philosophical paper |
Citations in the library
Cites 140
- A default mode of brain function Proceedings of the National Academy of Sciences January 16, 2001
- Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial Journal of Psychopharmacology November 30, 2016
- Interoceptive inference, emotion, and the embodied self Trends in Cognitive Sciences October 12, 2013
- Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial Journal of Psychopharmacology November 30, 2016
- Psilocybin can occasion mystical-type experiences having substantial and sustained personal meaning and spiritual significance Psychopharmacology July 7, 2006
and 135 more in the library