Background: Evidence is growing that psychedelic substances have positive effects in the setting of Palliative Care (PC), focusing on special needs in this patient population. After a scoping review of the literature, no published expert recommendations guiding best practice for psychedelic-assisted therapy (PAT) towards the end of life were identified. Objective: To draw conclusions from...
Addiction remains a persistent public health crisis, marked by poor treatment retention and limited pharmacotherapy options. Emerging treatments, such as psychedelic-assisted psychotherapy and neuromodulation, offer promising avenues for circuit-level interventions in behavioral addictions. This narrative review synthesizes the current landscape of psychedelic compounds and neuromodulation...
Psychedelic-assisted therapy (PAT) is an emerging intervention in psychiatry, for which there is preliminary evidence for effectiveness in eating disorders (EDs). The subjective psychedelic experience is considered an important driver of positive outcomes following PAT; however, conventional study design approaches often overlook many of the nuances inherent to the experience. Consequently,...
To the Editor: Psychedelic-assisted therapy (PAT) combines psychedelics, such as psilocybin, with guided psychotherapeutic support. 1 These substances interact with patient's mindset ("set") and the surrounding environment ("setting"), 2 making the context of the experience a critical factor in therapeutic outcomes.As these substances gain recognition for their therapeutic potential, it is...
Psychedelic-assisted therapy (PAT) has typically been evaluated using conventional randomised controlled trials (RCTs), which assess treatment efficacy under highly controlled conditions. However, PAT constitutes a complex intervention, integrating pharmacological, psychotherapeutic and contextual elements that interact dynamically with patient experiences and healthcare settings. Conventional...
abstract: Paul's concepts of "Transformative Experiences" (TE) has sparked extensive discussion on multiple epistemological and ethical issues within philosophy. In particular, Paul's work has inspired significant work on the possibility of informed consent with regard to medical interventions that may induce said TEs. One such intervention, namely Psychedelic-assisted Therapy (PAT), has been...
Preliminary evidence suggests that ayahuasca may alleviate severe grief symptoms. This three-arm, sequentially allocated, open-label study examines the therapeutic changes associated with ayahuasca-assisted meaning reconstruction therapy (A-MR) compared to meaning reconstruction therapy alone (MR) and a no-treatment control (NT). A total of 84 adults experiencing severe grief within 12 months...
Psychedelic substances have experienced a resurgence of clinical interest in recent years, particularly for their promising effects in the treatment of psychiatric disorders such as depression and anxiety. While evidence regarding their role in chronic pain management remains limited, emerging studies suggest potential therapeutic benefits. This case report describes a patient with persistent...
The resurgence of interest in psychedelic compounds as potential treatments for psychiatric disorders represents a paradigm shift in mental health care. Psychedelics exert their effects through serotonergic modulation, particularly via 5-HT2A receptor activation, inducing profound alterations in consciousness and catalyzing neuroplasticity. While their neurobiological effects are...
In recent years, renewed attention has been given to the centrality of set and setting inpsychedelic-assisted therapy. The Reporting of Setting in Psychedelic Clinical Trials (ReSPCT)guidelines reflect an evolving consensus: therapeutic outcomes are not solely pharmacologicallydetermined but are heavily shaped by both the environment and the psychological state of theparticipant...
Postepy psychiatrii neurologiiAugust 25, 2025Nikolaos Statharakos, Elisavet Papadopoulou, Aaron J. Alvares et al.1 citation
Purpose: Psychedelic substances are attracting attention for their therapeutic potential in mental health disorders. Emerging research suggests that even negative psychedelic experiences, or "bad trips," may hold therapeutic potential when managed in controlled settings. This narrative review explores the nature of "bad trips", their contributing factors, and their integration into therapeutic...
August 23, 2025Joseph M. Diehl, M. Zachary Rosenthal
preprint
Psychedelic-assisted psychotherapy (PAP) has emerged as a promising intervention for conditions such as depression, PTSD, and substance use disorders by enhancing the therapeutic potential of psychedelics with structured psychological support during preparation, dosing, and integration phases. Despite encouraging trial results, evidence for therapeutic mechanisms and optimal frameworks for PAP...
Abstract Background: Psychedelics can acutely induce mystical experiences and elevated positive mood, which may contribute to the potential benefits of psychedelic therapy. However, there remains limited understanding of the occurrence and importance of specific positive emotional experiences within psychedelic therapy. Therefore, we examined the effects of psychedelics on positive emotional...
1. Classical psychedelics are gaining attention as potential treatments for a range of neuropsychiatric conditions, including depression, anxiety, and addictions [1]. Psychedelics differ from tradi...
Abstract Background There has been a surge of interest in psychedelic research, especially with regards to the therapeutic properties of these compounds. This has led to the emergence of psychedelic assisted psychotherapy (PAP). PAP is showing promise for a range of mental health conditions, including major depressive disorder and PTSD, leading to (perhaps premature) international changes in...
Psilocybin-assisted psychotherapy appears safe and may offer durable relief from depression and anxiety in individuals with a life-threatening illness.
Our findings did not support that the amount of therapy hours influence depressive outcomes in PAT. However, this interpretation should be made with caution due to small sample sizes, heterogeneity, and poor reporting of the therapeutic component across studies. Future research should apply greater methodological rigor and standardized reporting of therapy to clarify its role in PAT.
INTRODUCTION: Methamphetamine use disorder (MeUD) is a debilitating condition with no FDA-approved pharmacotherapies that has been associated with poor neurological, psychiatric and cardiovascular outcomes, particularly among low-income populations. The use of methamphetamine also increases risks for sexually transmitted infections (STIs) by reducing behavioural inhibitions while enhancing...
Paul’s concepts of “Transformative Experiences” (TE) has sparked extensive discussion on multiple epistemological and ethical issues within philosophy. In particular, Paul’s work has inspired significant work on the possibility of informed consent with regard to medical interventions that may induce said TEs. One such intervention, namely Psychedelic-assisted Therapy (PAT), has been discussed...