Journal of Affective Disorders
March 1, 2025
Guy M. Goodwin, Scott T Aaronson, Oscar Alvarez et al.
35 citations
In treatment-resistant depression, a single dose of 25 mg of psilocybin produced stronger correlations between certain psychedelic experiences and depression improvement three weeks later than lower doses. The intensity of psychedelic effects was dose-related, but scores for different doses overlapped considerably. At the 25 mg dose, dimensions of oceanic boundlessness and visual restructuralization, along with emotional breakthrough, showed the strongest correlations with reduced depression scores. The study does not establish causation and requires replication. The overlap in experience intensity across doses suggests unblinding to dose is less likely. Correlations between psychedelic experience and outcome indicate specificity in psilocybin's mechanism of action.
Journal of Affective Disorders
February 15, 2023
Priel Meir, Leslie Taylor, Jair C Soares et al.
25 citations
Most psychologists are willing to inform eligible patients about psilocybin-assisted therapy if it becomes FDA-approved, but over 90% would still recommend non-psilocybin psychotherapies first. Among 119 surveyed psychologists, 77.4% agreed they would inform patients about PAT, yet 91.6% would prioritize other therapies. Three-quarters endorsed that more knowledge about psilocybin would increase their likelihood of informing patients. Greater openness to engaging patients with PAT was associated with more positive attitudes and beliefs about psilocybin, greater self-reported knowledge, personal psychedelic use, and positive attitudes toward medical cannabis. Attitudes toward medical cannabis and beliefs about psilocybin were the only significant predictors of openness in regression analysis.
Psychiatry Research
July 16, 2022
Thomas D Meyer, Priel Meir, Claudia Lex et al.
23 citations
Mental health professionals' attitudes toward psilocybin were neutral, but their self-rated knowledge of the substance was low. Whether the survey used the term 'Psilocybin' or 'Magic Mushrooms' did not significantly affect responses. Gender, attitudes toward medical cannabis, and personal history of psychedelic use were associated with ratings of psilocybin. These findings offer a baseline of mental health professionals' views on psilocybin, which may inform considerations if it receives FDA approval.
Psychedelic Medicine
August 18, 2023
Claudia Lex, Antonio F. Pagán, Jair C Soares et al.
9 citations
Medical students hold generally positive attitudes toward psychedelic-assisted therapy, but their attitudes are significantly more favorable when the term "psilocybin" is used instead of "magic mushrooms." Personal experience with psychedelics is linked to more positive attitudes, beliefs, and higher self-rated knowledge. Attitudes and beliefs are stronger predictors of willingness to recommend psychedelic-assisted therapy, if FDA approved, than personal experience alone. The findings suggest that using the term "psilocybin" may be preferable in research and educational contexts.
Journal of Affective Disorders
March 15, 2025
Thomas D Meyer, Maya Ibrahim, Lauren N Vale et al.
6 citations
People with bipolar disorder have been excluded from most psychedelic research due to concerns about triggering mania or psychosis. This study used the Timeline Followback method to assess mood symptoms, substance use, and mental health in individuals with bipolar disorder one month before and three months after their most recent recreational psychedelic experience. Depressive symptoms and cannabis use significantly decreased, and the number of days without mental health symptoms increased. There were no significant changes in manic, psychotic, or anxiety symptoms. The findings suggest psychedelics may be safe and potentially beneficial for bipolar disorder, but randomized controlled trials are needed.
Current Treatment Options in Psychiatry
November 11, 2025
Dan Petrovitch, Sarah E. Victor, A. Schmidt et al.
2 citations
The intense and distinctive subjective effects of psychedelics complicate tests of the efficacy and mechanisms of action of psychedelic-assisted treatments for mental-health conditions. Estimates of treatment efficacy are confounded under functional unblinding, and uncertainty surrounds whether subjective or neurobiological effects are causal mechanisms. Methodological solutions include improved active placebo conditions, expectancy-focused recruitment and consent procedures, better measurement of expectancies and blinding, and rigorous statistical modeling. Strategies to disentangle subjective and neurobiological effects include administering psychedelics under general anesthesia, developing non-psychoactive analogues, leveraging Mendelian randomization, and studying microdosing. Combining multiple innovative methods may offer the most robust insights.
Journal of Affective Disorders
February 1, 2026
Lauren N Vale, Maya Ibrahim, Leonardo Fávaro-pereira et al.
1 citation
People with bipolar disorder who have used classic psychedelics like psilocybin or LSD hold more positive attitudes toward these substances and score higher on openness to experience compared to those who are only considering use. The two groups do not differ in sociodemographic background or mental health status. Those who have used psychedelics endorse certain motives for use more strongly, while those contemplating use express greater concerns about potential negative effects. The findings suggest that prior psychedelic experience shapes perceptions and motivations, and highlight topics for discussion with individuals with bipolar disorder who may consider psychedelic use, including in clinical trials.
BMJ Open
July 13, 2026
Thomas D Meyer, Lauren N Vale, Maya Ibrahim et al.
A protocol describes an upcoming feasibility study testing psilocybin-assisted therapy in 10 outpatients with bipolar II disorder who have mild to moderate passive suicidal thoughts. Participants may receive two oral doses of 25 mg psilocybin about four weeks apart, combined with a structured mindfulness-based cognitive-behavioral therapy protocol. The study aims to assess the acceptability and safety of this approach, measuring changes in suicidality and depressive symptoms, and to gather preliminary data for a future randomized trial. Individuals with bipolar disorder and suicidality have typically been excluded from psilocybin trials due to safety concerns.
Journal of psychopharmacology (Oxford, England)
February 5, 2026
Benjamin R. Lewis, Matthew J Reid, Andrew M Novick et al.
Clinical trials of classical psychedelics like psilocybin for mental health conditions face unique challenges that may persist if these treatments enter clinical practice. Four categories of challenges with trial participants are identified: treatment nonresponse, expectancy effects and functional unblinding, post-session psychological difficulties, and contagion effects. Management strategies for study teams to mitigate these risks are described. The National Network of Depression Centers and similar organizations can guide best practices to responsibly advance this promising field.
J Affect Disord
October 10, 2025
Guy M. Goodwin, Scott T Aaronson, Oscar Alvarez et al.
correction
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