Journal of Pain and Symptom Management
March 1, 2026
William B Alexander, Eric D Hansen, Brian T Anderson et al.
1 citation
Meaning is a primary existential concern in those with advanced illnesses and functions as an important coping mechanism. Loss of meaning contributes to existential distress, and, in particular, may manifest as demoralization, a syndrome of poor coping that is associated with negative outcomes. Psychedelics are unique psychoactive compounds that, among other properties, are proposed to enhance...
Psychedelic Medicine
March 1, 2026
Sharday Mosurinjohn, Richard S. Ascough
5 citations
This article corrects an idea in psychedelic science and culture that the ancient Eleusynian Mysteries used psychedelics, as claimed by Carl Ruck and co-authors in The Road to Eleusis: Unveiling the Secret of the Mysteries (1978), revitalized by Brian Muraresku's The Immortality Key: The Secret History of the Religion with No Name (2020), and popularized by social media heavyweights such as Joe...
Therapeutic Advances in Psychopharmacology
March 1, 2026
Ana Deutsch, Luis E. Contreras, Sarah Kratina et al.
Background: Psychedelic therapies are gaining attention as tools to alleviate anxiety and depression across various clinical populations. However, the mechanisms behind psychedelics' therapeutic efficacy and the potential differences in how patients with certain diagnoses experience their subjective effects remain unknown. One commonly suggested mediator of positive outcomes across psychedelics...
Psychiatry Research
February 13, 2026
Sean P. Goldy, Nathan D. Sepeda, Samantha Hilbert et al.
1 citation
Psychedelics' characteristic acute subjective effects predict therapeutic benefits, such as decreases in depression and anxiety. Thus, optimizing treatment involves better understanding which factors shape subjective effects. Session facilitators, who support participants before, during, and after psychedelic administration sessions, form an important part of the setting of these experiences....
Journal of Psychopharmacology
February 5, 2026
Benjamin R. Lewis, Matthew J Reid, Andrew M Novick et al.
Classical psychedelics-a broad class of compounds that include psilocybin, lysergic acid diethylamide, dimethyltryptamine, and mescaline-have shown significant promise for the treatment of mental health conditions in recent clinical trials. Organizations such as the National Network of Depression Centers (NNDCs) can play a pivotal role in uniting researchers and clinicians working in this field...
Exploratory Research in Clinical and Social Pharmacy
February 4, 2026
Shreya Shiju, Rohan Tirumala, Elliot Marseille
Background: As public and scientific interest in psychedelics grows, unsupervised use for health purposes is increasing. In the U.S., past-year hallucinogen use nearly doubled from 2015 to 2023. Many individuals report self-treating physical or psychological symptoms without medical supervision using psychedelics—a practice termed self-medication. Despite this trend, review-level syntheses...
Psychiatry Research
February 2, 2026
Tatiana Aboulafia Brakha, Albert Buchard, Cédric Mabilais et al.
1 citation
Classic serotonergic psychedelics such as LSD and psilocybin show promising antidepressant effects in controlled trials, but real-world data from routine clinical care remain limited. This study retrospectively analysed routine data from adults with treatment-resistant depressive and/or anxiety disorders who received a first standardized Psychedelic-assisted Psychotherapy (PAP) cycle with 100...
Nervenheilkunde
February 1, 2026
Dimitris Repantis, Michael Koslowski, Felix Betzler et al.
Zusammenfassung Psychedelika wie Psilocybin und LSD durchlaufen eine bemerkenswerte Geschichte, die von frühen psychiatrischen Anwendungen über den Freizeitgebrauch und die Prohibition in den 70er Jahre bis zur aktuellen Wiederentdeckung in klinischen Studien reicht. MDMA wird seit etwa 15 Jahren für die Behandlung der posttraumatischen Belastungsstörung evaluiert. In der Behandlung werden...
Bioethics
February 1, 2026
Vojin Rakić
Various authors, including myself, have argued that happiness and morality operate in a circularly supportive relationship. In this paper, love will be added to this relationship. The new triple correlation will be explored through the following lens: not only do love and happiness reinforce moral action, but they appear to be in a triple circularly supportive relationship. Moral behavior is...
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
February 1, 2026
Katarzyna Kała, Dorota Bederska‐łojewska, Jan Lazur et al.
The growing percentage of people suffering from drug-resistant depression increases interest in alternative therapies, particularly the usage of psychedelics such as psilocybin. The main source of psilocybin is the Psilocybe cubensis species. Due to the potential therapeutic benefits of psilocybin and the legal restrictions on its possession and use in the form of fungal fruiting bodies, this...