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Michael Timothy Bennett, Sean Welsh
Please note this is a draft on which we are seeking feedback. Substantial changes and a third author are likely be added to the next version. The hard problem of consciousness asks why there is something it is like to be a conscious organism. We address this from 1st principles, by constructing a formalism that unifies lower and higher order theories of consciousness. We assume...
Azenet Liora Lopez Lopez preprint
Split-brain subjects can consciously perceive and identify two stimuli presented simultaneously but separately in opposite hemifields. Yet, they seem to lack a conscious experience of the two stimuli together, as they cannot judge whether these are the same or different. Such breakdowns in experiential or phenomenal unity would carry important implications for philosophical reflection on the...
Zümrüt Duygu Sen, Nitin Sharma, Lena Vera Danyeli et al. preprint
Along with its rapid therapeutic benefits, ketamine induces transient experience of dissociation during administration. Given the suggested association between ketamine-induced dissociation and treatment response, understanding the neural correlates of dissociation would help to elucidate its therapeutic mechanism. The posteromedial cortex (PMC) has been reported to play a vital role in the...
Tony R. Montgomery
Understanding how a simple endogenous tryptamine could occasion profound alterations in perception and self-modeling remains a key challenge for neuroscience. We advance the Birth Echo Hypothesis (BEH) : during a narrowly defined perinatal window (≈ −2 to +24 h around delivery), a convergence of hypoxic–hypercapnic stress, maximal sensory novelty, and a poly-neuromodulatory milieu...
Burton J. Tabaac, Kenneth Shinozuka, Anne Weisman et al. preprint
Background: 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), also officially known as Mebufotenin, is a naturally occurring serotonergic psychedelic alkaloid found in the venom of the Sonoran Desert toad (Incilius alvarius) and various plant species. Areas of Uncertainty: Trace levels of 5-MeO-DMT may be produced endogenously in humans, but its physiological role remains unclear. Safety profiles...
Kenneth Shinozuka, Burton J. Tabaac, Alejandro Arenas et al. preprint
Background: N,N-dimethyltryptamine (DMT) is a naturally-occurring serotonergic psychedelic found in natural plants around the globe. As the main psychoactive component in ayahuasca, which also contains monoamine oxidase (MAO) inhibitors, DMT has been consumed as plant-based brew by indigenous peoples for centuries. Further research is required to delineate the therapeutic utility of DMT.Areas...
Juan Ignacio Amaro Fuenzalida
The present study addresses the problem of consciousness from the perspective of its phenomenological content (awareness). It examines the main contemporary theories concerning the neural correlates of consciousness, focusing on the Global Neuronal Workspace Model (GNWM) and the Higher-Order Theory (HOT). While the GNWM proposes that conscious access arises from the propagation of sensory...
Anthony Paul Zanesco, Brandon G King, Katherine A Maclean et al. 1 citation
Various forms of mental training have been shown to improve performance on cognitively demanding tasks. Individuals trained in meditative practices, for example, show generalized improvements on a variety of tasks assessing attentional performance. A central claim of this training, derived from contemplative traditions, posits that improved attentional performance is accompanied by subjective...
Pedro A. M. Mediano, Fernando E. Rosas, Andrea I. Luppi et al. 10 citations
Abstract Quantifying the complexity of neural activity has provided fundamental insights into cognition, consciousness, and clinical conditions. However, the most widely used approach to estimate the complexity of neural dynamics, Lempel-Ziv complexity (LZ), has fundamental limitations that substantially restrict its domain of applicability. In this article we leverage the information-theoretic...