American Journal of Therapeutics
Burton J. Tabaac, Kenneth Shinozuka, Alejandro Arenas et al.
14 citations
The primary psychoactive drug in magic mushrooms, psilocybin, induces profound alterations in consciousness through the 5-HT2A receptor. This review consolidates current research findings to elucidate the pharmacology, safety profile, and clinical applications of psilocybin. Despite initial concerns that psilocybin could cause psychosis, contemporary research has demonstrated that psilocybin is...
December 2, 2026
Joe Gough
Abstract: The concept of mind and the category of the mental are hugely influential. They are also fundamentally mistaken. They are ill-suited to describing human beings and our place in the world. They are recent, culturally specific, theoretically motivated, and value-laden. They mislead us about ourselves, nonhumans, the nature of psychology, psychiatry, and cognitive science, the nature of...
Neuroethics
December 1, 2026
Guy Simon, James W. Hopper, Aaron D. Cherniak et al.
Abstract: Psychedelic-assisted therapy (PAT) is increasingly used for trauma-related disorders, raising ethical questions beyond client safety. We argue that PAT clients have epistemic needs and clinicians have corresponding obligations that call for epistemic humility and discipline, which are essential for regulating foreseeable epistemic risks and for PAT's ethical structure. Drawing on...
Bodea Marius
preprint
Abstract The question of whether artificial systems can become conscious has long been trapped between philosophical claims and engineering denials. Recent advances in large language models have intensified this debate, but progress requires moving beyond either credulity or dismissal toward testable architectural hypotheses. This study begins with an unexpected provocation, a self-described AI...
Stephanie J. Tepper
Research on flow, a positive emotional experience characterized by full absorption, involvement, and enjoyment during an activity, has primarily focused on the individual benefits of this mental state. In the present study, I investigate the mechanisms by which flow may produce changes in social orientation such that the boundaries between the self and other are diminished. In a 2x2 study,...
Grace Kiernan, Anneke Sools, Tim Alber et al.
preprint
Objective: This study explores experiences of social adversity and changes in social functioning from the perspectives of individuals with early psychosis.Method: Interviews were conducted with N=14 individuals with early psychosis and analysed using Interpretative Phenomenological Analysis.Results: Four overarching themes reflecting varying experiences of social adversity and functioning were...
Soumyajit Karmakar
Reduced spontaneous thought during meditation is often described phenomenologically, but a mechanistic account should specify how a dynamical system can enter and persist in such a regime. Here we formulate a minimal statistical-mechanical model in which a dimensionless coordinate, q, represents a coarse-grained propensity for spontaneous-thought activity, and a slowly relaxing variable, r of...
Marsel Fazlyyyakhmatov, Vladimir Antipov
In this article, the perception of 3D attributes (depth, volume and spatial perspective) is examined from the perspective of creativity, the anticipation phenomenon and the quantum theory of consciousness. The aim of the work is to consider activation of the incubation and insight processes under the influence of flat images in the modern visual environment. It is shown that not only can people...
Minkyung Kim, UnCheol Lee
preprint
Abstract: Brain networks during unconscious states resulting from sleep, anesthesia, or traumatic injuries are associated with a limited capacity for complex responses to stimulation. Even during the conscious resting state, responsiveness to stimulus is highly dependent on spontaneous brain activities. Many empirical findings have been suggested that the brain responsiveness is determined...
Vidushani Dhanawansa, Devon Stoliker, Leonardo Novelli et al.
Background: Psilocybin is a serotonergic psychedelic that provides a pharmacological tool for examining neural activity associated with altered states of consciousness. Existing studies report reduced power (4-30 Hz) in posterior regions and altered functional connectivity (FC) at rest, but have typically involved small samples and coarse anatomical parcellations. Additionally, perceptual...