Journal of Psychopharmacology
May 29, 2026
Kristoffer Brendstrup‐brix, Brice Ozenne, Patrick M. Fisher et al.
Patients with chronic cluster headache (CCH) suffer from poor sleep, which may impact their brain microstructure and parenchymal clearance of waste products. Psilocybin has shown promise for the treatment of CCH and has been linked to increased neuroplasticity with possible influences on brain microstructure. To investigate the effects of psilocybin on sleep, brain water diffusivity, and...
Clinical Pharmacology & Therapeutics
May 28, 2026
Gia Han Le, Sabrina Wong, Danica E. Johnson et al.
Major depressive disorder (MDD) and treatment-resistant depression (TRD) remain leading causes of disability, providing the impetus for receptor-level treatment strategies beyond monoamine reuptake. The serotonin 5-HT2B receptor (5-HT2BR) is uniquely positioned at the interface of central-antidepressant mechanisms and peripheral cardiac risks. Herein, we reviewed preclinical, translational and...
Advances in Social Sciences Research Journal
May 26, 2026
Erik Gadotti, Edoardo Casiglia
This article aims to present a model to explain the phenomenology of hypnosis, with particular reference to plastic monoideism and its phenomenology, integrating some of the current scientific theories of consciousness, particularly those of Karl Friston's free energy theory. Experimental studies demonstrate the existence of a close relationship between the individual's representational system...
Translational Psychiatry
May 26, 2026
Marvin M. Urban, Lea Zillich, Nathalie M. Rieser et al.
1 citation
The serotonergic hallucinogen psilocybin has shown potential as a treatment for psychiatric conditions like alcohol use disorder (AUD) and depression in clinical studies. Epigenetic mechanisms, including DNA methylation, are hypothesized to contribute to its lasting therapeutic benefits. In this exploratory study, we present the first methylome-wide analysis of psilocybin-induced changes in a...
Discover Mental Health
May 25, 2026
Filip Blazek, Klara Latalova, David Krahulik et al.
Psychedelic-assisted therapy and neurostimulation represent converging approaches to modulating dysfunctional brain circuits in treatment-resistant psychiatric disorders. This Perspective outlines shared mechanisms involving neuroplasticity and network reconfiguration, and examines ethical, regulatory, and infrastructural barriers to their translation. Bridging neuroscience, psychiatry, and...
Translational Psychiatry
May 21, 2026
Francesco Bavato, Andrea E. Steuer, Anna M. Jacobsen et al.
Methamphetamine (METH, "Crystal Meth") and 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") are two types of substituted amphetamines that share structural-chemical similarities but exhibit contrasting acute and chronic effects including addictive liability. Tryptophan (TRY) pathways are involved in pleiotropic physiological functions at the interface of brain-body connections. Preclinical...
Frontiers in Pharmacology
May 19, 2026
Fernanda Pilatti, Marieli Philippsen, A. G. Bertollo et al.
Major Depressive Disorder (MDD) is a highly prevalent and disabling psychiatric disorder, representing a major global health burden across all age groups. Increasing evidence indicates that its pathophysiology involves a complex interplay between chronic stress, dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, immune activation, and neuroinflammation. Persistent HPA axis...
May 19, 2026
Vanessa Bibliowicz
In Chapter 9 , I explore the integration phase of psychedelic-assisted therapy, highlighting its crucial role in translating psychedelic experiences into lasting personal transformation. Integration is the active process of incorporating the insights and emotional breakthroughs from psychedelic journeys into everyday life. The chapter emphasizes the need for structured therapeutic practices...
May 19, 2026
Vanessa Bibliowicz
This chapter explores the evolution of psychedelics from ancient rituals to modern neuroscience. It begins with a historical overview of their use in spiritual and communal healing, then traces the scientific discoveries that followed—from early psychiatric research to current clinical trials. The chapter then introduces how psychedelics affect the brain, especially through their impact on the...
Zenodo (CERN European Organization for Nuclear Research)
May 17, 2026
Tenzin Trepp
preprint
Emerging research in contemplative science and psychedelic neuroscience suggests that deeply entrenched patterns of selfhood and cognition—often associated with mental disorders like depression—can be profoundly altered through both meditative practice and pharmacological intervention. This paper presents a neuroconstructivist framework for understanding how deep meditation and dissociative...