Neuroplasticity: all studies (page 29) - The Consciousness Library

[Clinical application and mechanistic studies of psychedelics for treatment of depression: progress and future challenges].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University January 20, 2026 Ke Xia, Tianming Gao

Depression is a complex and globally prevalent mental disorder, for which conventional antidepressant medications face limitations such as delayed onset and insufficient efficacy. Classic psychedelics, most notably psilocybin, have recently emerged as promising candidates for treatment of depression and demonstrated rapid, robust, and sustained antidepressant effects in controlled clinical...

DOI: 10.12122/j.issn.1673-4254.2026.01.01 Full text Neuroplasticity Psilocybin 5-hydroxytryptamine receptor 2a Antidepressant +1

Neural Dynamics of Heartfulness Meditation: EEG Alpha Modulation Across Experience Levels.

Annals of Neurosciences January 19, 2026 Gyaneshwar Singh, Saleema Js, Krishna Dwivedi et al.

Background: Electroencephalography (EEG) studies consistently associate alpha-band oscillations with relaxation, internalized attention, and sensory disengagement during meditation. However, limited evidence exists on how Heartfulness Meditation (HM), particularly its unique transmission phases, modulates alpha activity across different experience levels. Purpose: This study investigated...

DOI: 10.1177/09727531251400095 Full text Neuroplasticity Neural oscillations Heartfulness meditation EEG Alpha Band +1

Modeling Antidepressant-Induced Manic Switch and Longitudinal Relapse: A Unified Pruning Framework Highlights Glutamatergics' Disease-Modifying Potential

Zenodo (CERN European Organization for Nuclear Research) January 19, 2026 Ngo Cheung 1 citation preprint

Background: Major depressive disorder involves impaired neural plasticity, yet antidepressants targeting glutamatergic (ketamine), monoaminergic (SSRIs), and GABAergic (neurosteroids) pathways differ markedly in onset speed, durability, and risk of treatment-emergent mania—particularly in bipolar contexts. Clinical comparisons are confounded by heterogeneity; computational models enable...

DOI: 10.5281/zenodo.18298989 Neuroplasticity Bipolar disorder Synaptic pruning Monoaminergic +2

The impact of homeostatic inhibitory plasticity in a generative biophysical model

bioRxiv (Cold Spring Harbor Laboratory) January 13, 2026 Iván Mindlin, Carlos Coronel-Oliveros, Jacobo Sitt et al. preprint

A main characteristic of biological systems is their capacity to dynamically adapt to environmental changes. In the brain, synaptic plasticity enables the strengthening or weakening of connections between neurons, allowing neural circuits to adapt based on experience, learning, and environmental changes. Yet, it is homeostatically regulated such that it avoids excessive proliferation of...

DOI: 10.64898/2026.01.12.699008 Synaptic plasticity Neuroplasticity Homeostatic plasticity Asynchronous communication +15

An exploration of the relationships between the effects of psilocybin on behavior, 5-HT 2A receptor occupancy, and neuroplastic effects in mice

Journal of Psychopharmacology January 6, 2026 Connor J. Maltby, Adam K. Klein, Enya Paschen et al. 3 citations

Background: Psilocybin has shown rapid and sustained antidepressant effects in patients with major depressive disorder, yet the neurobiological mechanisms underlying these outcomes remain unclear. Aims: This study aimed to bridge clinical and preclinical findings by investigating the relationships between 5-HT 2A receptor occupancy (RO) achieved after administration of psilocybin and its...

DOI: 10.1177/02698811251395386 Neuroplasticity Psilocybin Synaptic plasticity Prefrontal cortex +7

From multisensory integration to synaesthesia: a boundary-preserving continuum and research framework.

Frontiers in Psychology 2026 Kaiyu Qiu, Zixiu Jiang, Ke Jiang et al.

Synaesthesia is commonly defined as an involuntary and consistent phenomenon in which stimulation in one sensory or cognitive domain elicits an additional experience in another domain. Yet definitions derived from perceptual psychology, neuroscience, aesthetics, cultural anthropology, and artistic practice often speak past one another. This article proposes a boundary-preserving conceptual...

DOI: 10.3389/fpsyg.2026.1893904 Full text Neuroplasticity 4e cognition Cross-modal correspondence Education +4

Advances in drug addiction research using Caenorhabditis elegans: behavioral and molecular mechanisms.

Frontiers in Cell and Developmental Biology 2026 Lihua Yang, Shuang Wu, Jiale Liu et al.

Drug addiction is a complex, chronic, and relapsing neurological disorder characterized by persistent neuroadaptation and a substantial public health burden. Because of its simple nervous system, genetic tractability, short life cycle, transparent body, and quantifiable behavioral phenotypes, C. elegans (Caenorhabditis elegans) has become a useful complementary model for studying selected...

DOI: 10.3389/fcell.2026.1880079 Full text Neuroplasticity Caenorhabditis elegans Behavioral changes Drug addiction +1

A caveat regarding the unfolding argument: implications of plasticity.

Neuroscience of Consciousness 2026 Vikas O'Reilly-Shah, Alessandro Maria Selvitella, Aaron Schurger

The unfolding argument in the neuroscience of consciousness posits that causal structure cannot account for consciousness because any recurrent neural network (RNN) can be "unfolded" into a functionally equivalent feedforward neural network (FNN) with identical input-output behavior. Subsequent debate has focused on dynamical properties and philosophy of science critiques. We examine a boundary...

DOI: 10.1093/nc/niag027 Full text Neural plasticity Takens’ theorem Consciousness Dynamical systems +4

Allostatic Recalibration Theory (ART): Serotonergic Psychedelics Exert Transdiagnostic Therapeutic Effects by Recalibrating Allostasis to the Environment

SSRN Electronic Journal 2026 Dennis Parker Kelley, Gabriel Sturm, Katy Venable et al. preprint

Serotonergic psychedelics produce therapeutic effects in clinical trials of diverse neuropsychiatric disorders, and preclinical models of inflammatory, cardiometabolic, and neuropsychiatric diseases. These effects appear largely mediated by the serotonin 5-HT2A receptor (5-HT2AR). How could psychedelics elicit transdiagnostic therapeutic effects through a single receptor across tissues as...

DOI: 10.2139/ssrn.6598058 Serotonergic Neuroplasticity Allostatic load Allostasis +5

Transient multidomain functional improvement in advanced Alzheimer's disease following high-dose psilocybin-containing mushroom administration: a case report.

Frontiers in Neuroscience 2026 Marcos Lago, Mariana Cerveira, Joe Xavier Simonet 1 citation

Advanced Alzheimer's disease (AD) is generally regarded as a stage of irreversible functional decline. Psilocybin is known to transiently alter large-scale brain network dynamics and to induce plasticity-related mechanisms in preclinical models, yet clinical data in advanced dementia remain lacking. We report the case of an octogenarian Japanese-American woman with a 10-year history of...

DOI: 10.3389/fnins.2026.1813281 Full text Neuroplasticity Psilocybin Alzheimer’s disease Advanced dementia +1