Proceedings of the National Academy of Sciences
August 15, 1995
A V Ferrer-Montiel, W Sun, M Montal
The N-methyl-D-aspartate receptor (NMDAR), a pivotal entity for synaptic plasticity and excitotoxicity in the brain, is a target of psychotomimetic drugs such as phencyclidine (PCP) and dizolcipine (MK-801). In contrast, a related glutamate receptor, the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate/kainate receptor GluR1, is weakly sensitive to these drugs. Three point mutations on...
Harvard Review of Psychiatry
Christopher W. T. Miller, Zofia Kozak
2 citations
As practitioners seek more personalized approaches, exploring how patients' environments, relationship templates, and mindsets factor into symptom burden can help broaden understanding of how psychotropic medications facilitate recovery. Despite increasing focus on medications to provide relief, there is an important and undeniable influence the therapeutic environment has on shaping outcomes,...
Denis Larrivee, Diane Steele
From pharmacological manipulation to interfacial neurotechnologies, approaches to neuroenhancement span a broad and expanding technology spectrum. Many such procedures introduce profound changes in brain function, oftentimes with serious health risks. The Presidential Commission for the study of Bioethical issues (Gray Matters II, 2015), by contrast, has recommended enhancement protocols that...
Valeria Serra, Federico Brandalise, Vivien Miczán et al.
Abstract Dynamic regulation of midbrain dopamine neuron activity is necessary for diverse processes including motivation, novelty detection, reinforcement learning, and cognitive flexibility. By setting the strength of synaptic inputs to dopaminergic neurons, endocannabinoid signaling is essential for regulating dopaminergic activity. Prenatal exposure to Δ9-tetrahydrocannabinol (THC), the main...
Olivier J. J. Manzoni, Alba Cáceres-Rodríguez, Daniela Iezzi et al.
preprint
Abstract Prenatal cannabidiol (CBD) consumption is rapidly increasing, driven by a perception of safety relative to delta9-tetrahydrocannabinol (THC). However, the long-term neurodevelopmental risks of gestational CBD remain largely uncharacterized. Using a sex-disaggregated framework, we investigated adult (P100–140) mouse offspring following in utero exposure (GD5–18; 3 mg/kg) to THC or CBD....
Soukaina Es-Safi, Céline Bourcier-Lucas, Erika Abrial et al.
preprint
ABSTRACT Ketamine at subanaesthetic dose is known as a fast-acting antidepressant (AD), able to facilitate synaptic plasticity in the medial prefrontal cortex (mPFC) or the hippocampus. However, its influence on the serotonergic (5-HT) system is more confusing as it loses its behavioral effects in 5-HT-depleted animals, but does not modify 5-HT neuron function. We hypothesized that this...
Liming Xiu
This article critiques the philosophical underpinnings of current electronics in Moore's Law 1.0, arguing that progress remains constrained by reductionist engineering and an implicit commitment to mind-body dualism. Despite advances in computational power, digital computation remains fundamentally mechanistic and fails to bridge the gap between physical process and subjective experience....
preprint
Human exploration of consciousness and cognition has persisted for decades, yet a universally accepted physical definition and formation mechanisms for these phenomena remain elusive. Against this backdrop, this work establishes a systematic theoretical framework from the perspectives of physics and informatics to define consciousness and cognition conceptually and elucidates their formation...
Ernesto Estrada
preprint
Theories of consciousness frequently emphasize integration, differentiation, recurrent processing, or global availability, but the mathematical organization connecting neural propagation with subjective experience remains unclear. We introduce the Geometro–Diffusion Theory (GDT), in which diffusion-like dynamics on a structured substrate induces an intrinsic relational geometry. We introduce...
Marta Navarrete, Cristina Martín-Monteagudo, Nagore Puente et al.
preprint
Abstract Cannabis is the most widely used illicit drug, particularly during adolescence, and its consumption disrupts glutamate homeostasis and synaptic plasticity in the nucleus accumbens (NAc). While astrocytic cannabinoid receptors (CB1Rs) are known to modulate synaptic plasticity and behavior, the extent to which specific astrocytic ensembles drive tetrahydrocannabinol (THC)-induced...