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International Journal of Applied and Fundamental Research (Международный журнал прикладных и фундаментальных исследований) 2020 I. Kanunikov, Y. Kuperin, G. Chernykh
МЕДИТАЦИЯ И НЕЙРОПЛАСТИЧНОСТЬ. РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЯ ДЗАДЗЕН МЕДИТАЦИИ С ПОМОЩЬЮ РЕКУРРЕНТНОЙ ЭНТРОПИИ ЭЭГКануников И
The Journal of Alternative and Complementary Medicine December 1, 2019 Dipti Magan, R. Yadav, C. Bal et al.
Objective: Previous studies evaluating neurophysiological correlates of long-term meditation are constrained by some methodological limitations. The objective of this study was to measure changes in the regional cerebral glucose metabolism during meditation using a novel methodological approach. Design: The present study was a part of a larger, nonrandomized, single-center open-label study....
Neuropharmacology November 1, 2019 Jun Yamada, Shozo Jinno
Recent studies have shown that ketamine, an open channel blocker of the N-methyl-d-aspartate receptor (NMDAR), is effective for patients with treatment-resistant depression. In this study, we aimed to elucidate the potential link between antidepressant-like effects of a single ketamine administration and dorsoventral differentiation in adult hippocampal neurogenesis. Immunohistochemical...
Journal of Psychopharmacology September 2019 Sonia Abad, Carla Ramon-Duaso, Raúl López‐arnau et al.
3,4-Methylenedioxymethamphetamine (MDMA) is still one of the most consumed drugs by adolescents. Its abuse is related with cognitive impairment, which seems due to maladaptive plasticity and neural stress. In turn, new hypotheses suggest that Alzheimer's disease (AD) may be promoted by neural stressors. To test if there is an increase in vulnerability to AD after chronic MDMA consumption, we...
Entropy (Basel, Switzerland) May 24, 2019 Leigh Sheneman, Jory Schossau, Arend Hintze
Information integration theory has been developed to quantify consciousness. Since conscious thought requires the integration of information, the degree of this integration can be used as a neural correlate (Φ) with the intent to measure degree of consciousness. Previous research has shown that the ability to integrate information can be improved by Darwinian evolution. The value Φ can change...
IBRO Reports January 16, 2019 Michael Zhang, Kennett D. Radford, Mercedes Y. Driscoll et al. 34 citations
Ketamine, a multimodal dissociative anesthetic, is a powerful analgesic administered following trauma due to its hemodynamic and respiratory stability. However, ketamine can cause hallucination and dissociation which may adversely impact traumatic memory after an injury. The effects of ketamine on proteins implicated in neural plasticity are unclear due to different doses, routes, and timing of...
Neuropharmacology November 2018 Rachael Ingram, Heather Kang, Stafford Lightman et al.
Ketamine, a channel blocking NMDA receptor antagonist, is used off-label for its psychedelic effects, which may arise from a combination of several inter-related actions. Firstly, reductions of the contribution of NMDA receptors to afferent information from external and internal sensory inputs may distort sensations and their processing in higher brain centres. Secondly, reductions of NMDA...
Acta Physiologica October 22, 2018 Henrik Michaëlsson, Mats Andersson, Johan Svensson et al. 28 citations
AIM: Major depressive disorder is a common and debilitating condition with substantial economic impact. Treatment options, although effective, are aimed at relieving the symptoms with limited disease modification. Ketamine, a commonly used anaesthetic, has received substantial attention as it shows rapid antidepressant effects clinically. We studied the effects of ketamine on hippocampal...
Biological Psychiatry October 15, 2018 Sade M Spencer, Daniela Neuhofer, Vivian C Chioma et al.
Cannabis is the most widely used illicit drug, but knowledge of the neurological consequences of cannabis use is deficient. Two primary components of cannabis are Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD). We established a THC+CBD model of self-administration and reinstated drug seeking to determine if, similar to other addictive drugs, cannabis produces enduring synaptic changes in...
Biological Psychiatry September 20, 2018 Samuel T. Wilkinson, Paul E. Holtzheimer, Shan Gao et al.
Until recently, therapeutic development in psychiatry was targeted solely toward symptom reduction. While this is a worthwhile goal, it has yielded little progress in improved therapeutics in the last several decades in the field of mood disorders. Recent advancements in our understanding of pathophysiology suggests that an impairment of neuroplasticity may be a critical part of the development...