This essay looks into the complex philosophical connection between Nāda (sound) and Nirvāna (liberation) in different Indian philosophical systems, such as Buddhism, Vedānta, and Sākhya. It looks at how sound works not only as an audible experience but also as a basic ontological principle that connects what is real and what is not real. The study looks at the different ways Indian thinkers...
Background: The Psychological Insight Questionnaire (PIQ), the Emotional BreakthroughInventory (EBI), and the Psychological Insight Scale (PIS) have been developed to assess the subjective effects of psychedelic experiences, in order to better understand the therapeutic mechanism of psychedelic-assisted therapy. This study aimed to evaluate Dutch translations of these questionnaires (the...
Objective. Resting electroencephalographic activity is typically indistinguishable from a filtered linear random process across a diverse range of behavioural and pharmacological states, suggesting that the power spectral density of the resting electroencephalogram (EEG) can be modelled as the superposition of multiple, stochastically driven and independent, alpha band (8-13 Hz) relaxation...
Spirituality and the occult represent important aspects of Maud Gonne’s life and writings, and their investigation offers an unusual perspective on this famous icon of revolutionary Ireland. Her memoir and letters to Yeats testify to a lasting relationship with “the spirit world” in as diverse forms as Celtic mysticism, occult practices, psychic phenomena, and the Catholic faith. By...
Consciousness is a fundamental component of cognition, 1 but the degree to which higher-order perception relies on it remains disputed. 2,3 Here we demonstrate the persistence of learning, semantic processing, and online prediction in individuals under general anesthesia-induced loss of consciousness. 4,5 Using high-density Neuropixels microelectrodes 6 to record neural activity in the human...
Psilocybin-assisted therapy (PAT) has gained recognition as an innovative intervention in hospice and palliative care, demonstrating potential in mitigating the psychological, spiritual, and existential distress experienced by patients with serious illnesses. This article explores the role of PAT within these care settings, emphasizing its influence on various dimensions of human suffering, as...
Introduction One of the main mechanisms of action of LSD in psychedelic-assisted psychotherapy (PAP) is the activation of 5HT2A receptors. This triggers a cascade of neurochemical processes with the release of neurotransmitters and neurohormonal substances. The release of oxytocin in this process is well documented in pre-clinical studies, with recent evidence in healthy subjects. We have no...
Abstract:Jīva Gosvāmin (16th–17th c.), one of the most important of the early Gauḍīya Vaiṣṇava theologians, argues for a unique theory of mystical pluralism that shares critical parallels with the highly influential constructivist thesis advanced by Steven Katz, albeit separated by more than four hundred years. These parallels suggest a shared insight into the cognitive dynamics underpinning...
Psychedelic-assisted therapy (PAT) involves supported experiences with psychedelic medicines in carefully curated environments. Early evidence suggests possible utility of PAT for addressing psychosocial-spiritual-existential concerns, yet gaps remain in understanding findings related to PAT's role in palliative care. This rapid review aims to synthesize current literature on applications of...
Lysergic acid diethylamide (LSD) is gaining renewed interest as a potential treatment for anxiety, depression, and alcohol use disorder, with clinical trials reporting significant symptom reductions and long-lasting effects. LSD modulates serotonin (5-HT2A) receptors, which, in turn, influence dysfunctional brain networks involved in emotional processing and cognition. It has also shown promise...