Technoetic Arts
June 1, 2021
Lucas Pawlik
Data analysis from diverse medical fields suggests that we have reached a tipping point in the digitalization dynamic through the ongoing COVID-19 crisis, leading to an escalation of physical inactivity and related diseases. The lack of prioritization of physical activity designed to intervene against obesity, diabetes, loneliness, depression, anxiety disorders and suicide risk could...
Trials
April 23, 2021
Robin J Murphy, Rachael Sumner, William Evans et al.
23 citations
BACKGROUND: Regular ingestion of sub-hallucinogenic doses of psychedelics, referred to as "microdosing", has gained increasing popularity and attention in the press and in online forums, with reported benefits across multiple cognitive and emotional domains. Rigorously controlled studies to date, however, have been limited in scope and have failed to produce results comparable to those reported...
Frontiers in Pharmacology
February 26, 2021
Guy A. Higgins, Nicole K. Carroll, Matthew A. Brown et al.
67 citations
Long term benefits following short-term administration of high psychedelic doses of serotonergic and dissociative hallucinogens, typified by psilocybin and ketamine respectively, support their potential as treatments for psychiatric conditions such as major depressive disorder. The high psychedelic doses induce perceptual experiences which are associated with therapeutic benefit. There have...
The Journal of Clinical Psychiatry
February 23, 2021
Avinash Hosanagar, Joseph Cusimano, Rajiv Radhakrishnan
1 citation
P sychedelics have recently gained attention as compounds with therapeutic potential in the treatment of psychiatric disorders.The US Food and Drug Administration (FDA) has granted Breakthrough Therapy Designations for (±)-3,4-methylenedioxymethamphetamine (MDMA) as an adjunct to psychotherapy in severe posttraumatic stress disorder (PTSD) (in 2017) and for the adjunctive use of psilocybin with...
5-HT2B Receptors
2021
Dino Luethi, Matthias E. Liechti
3 citations
Stimulant and psychedelic drugs of abuse exert their effects through interactions with monoaminergic systems. Compared to other monoaminergic receptors and transporters, the 5-hydroxytryptamine 2B (5-HT_2B) receptor represents a relatively little studied target of serotonergic drugs of abuse. However, studies suggest the involvement of 5-HT_2B receptors in the mechanism of action of...
Journal of Psychoactive Drugs
November 26, 2020
Heba Diab, Benjamin Malcolm
1 citation
This case report describes a 39-year-old male with remote history of polysubstance use disorder and depression who developed tinnitus after use of inhaled N,N-dimethyltryptamine (DMT). Although development of ear ringing was attributed to use on a single occasion, tinnitus occurred within the context of a larger self-experiment involving weekly microdoses of lysergic acid diethylamide (LSD)....
Drug Testing and Analysis
October 29, 2020
Klára Gotvaldová, Kateřina Hájková, Jan Borovička et al.
69 citations
Abstract Psilocybin, psilocin, baeocystin, norbaeocystin, and aeruginascin are tryptamines structurally similar to the neurotransmitter serotonin. Psilocybin and its pharmacologically active metabolite psilocin in particular are known for their psychoactive effects. These substances typically occur in most species of the genus Psilocybe (Fungi, Strophariaceae). Even the sclerotia of some of...
European Neuropsychopharmacology
October 17, 2020
Nadia R. P. W. Hutten, Natasha L. Mason, Patrick C. Dolder et al.
121 citations
There is a popular interest in microdosing with psychedelics such as LSD. This practice of using one-tenth of a full psychedelic dose according to a specific dosing schedule, anecdotally enhances mood and performance. Nonetheless, controlled research on the efficacy of microdosing is scarce. The main objective of the present dose-finding study was to determine the minimal dose of LSD needed to...
Critical studies in risk and uncertainty
October 13, 2020
Anita Hardon
1 citation
Abstract The microdosing of mind-altering substances, like LSD and magic mushrooms, is a trend among young creatives, who report enhanced creativity, improved focus, and other productivity-enhancing effects. This chapter, Chemical Creativity , describes how both users and researchers have been exploring the range of effects of microdosing, including through more experimental ethnographic...
American Journal of Management
October 2, 2020
Lawrence Silver
2 citations
There is a long history of psychedelic use throughout history. A great deal of research was conducted on the possible benefits of psychedelics until LSD and psilocybin became street drugs in the 1960s with reported negative effects. Declared illegal in the late 1960s, research slowed on the benefits of such drugs. A new version of the “street” use of psychedelics has emerged in the form of...