Journal of Clinical Oncology
February 1, 2023
Lyudmyla Demyan, Oliver Standring, Taemoon Chung et al.
742 Background: Current biomarkers offer modest predictive capacity for drug sensitivity testing in pancreatic cancer. Patient-specific pharmacotyping offers the potential for a more direct, personalized prediction model. Recently, an implantable microdevice was developed to facilitate in situ multi-agent pharmacotyping and has since entered clinical trials in multiple cancer types, but had not...
Sensors
January 20, 2023
Víctor Cuadrado-Peñafiel, Adrián Castaño-Zambudio, Luis Manuel Martínez-Aranda et al.
Introduction: The implementation of optimal sprint training volume is a relevant component of team sport performance. This study aimed to compare the efficiency and effectiveness of two different configurations of within-season training load distribution on sprint performance over 6 weeks. Methods: Twenty male professional FH players participated in the study. Players were conveniently assigned...
Journal of Psychedelic Studies
January 17, 2023
Ioana Pop, Jannis Dinkelacker
4 citations
Abstract Background and aims Previous research has proposed that microdosing, i.e., the repeated use of sub-threshold doses of serotonergic hallucinogens, has an impact on mood by increasing emotional awareness. We propose that increased emotional awareness could translate into higher emodiversity, a balanced experience of emotions in which emotions are experienced with more similarity in...
Substance Use & Misuse
2023
Barbara Andraka-Christou, Matthew Douglas Evans, Beth Tranen et al.
Background: Opioid overdose deaths in the U.S. continue to increase, largely due to the prevalence of fentanyl, a very powerful opioid, in the illicit drug supply. Buprenorphine treatment is effective for treating opioid use disorder, but it can be challenging for clinicians to introduce buprenorphine treatment to people who use fentanyl due to risks of precipitated withdrawal. Induction could...
Base
2023
André Adjogboto, Dagnon Didier Likpètè, C. Sossa-Vihotogbe et al.
Description of the subject. Fertilizers microdosing was tested for African leafy vegetables (ALVs) production to reduce the high rates of fertilizers usually applied to their production in West Africa. Objectives. This study aims to (i) evaluate the response of three ALVs (Amaranthus cruentus L., Solanum macrocarpon L. and Ocimum gratissimum L.) to cattle manure combined with urea-N microdosing...
Journal of Labelled Compounds and Radiopharmaceuticals
2023
Yong Gong, Rhys Salter
Ibrutinib is an oral medication for the treatment of B cell malignancies. During its clinical development, a stable isotopologue of ibrutinib was required for the assessment of the drug's absolute oral bioavailability via intravenous microdosing. The following work describes a 10‐step, gram‐scale production of carbon‐13 labeled ibrutinib from [13C6]phenol (13C6, 99%) in 31% overall yield with...
KWI-Blog
2023
Stefan Höhne
2 citations
2023-07-24
Neuropsychopharmacology
2023
James Glazer, Conor H. Murray, Robin Nusslock et al.
52 citations
Renewed interest in classic psychedelics as treatments for psychiatric disorders warrants a deeper understanding of their neural mechanisms. Single, high doses of psychedelic drugs have shown promise in treating depressive disorders, perhaps by reversing deficits in reward processing in the brain. In addition, there are anecdotal reports that repeated ingestion of low doses of LSD, or...