EXCLI journal2026Chun-Hua Xu, Bi-Lan Zhang, Chun-Lan Guan et al.
Mindfulness-based cognitive therapy (MBCT) demonstrates significant efficacy in improving depressive symptoms and modulating metabolic profiles. However, the specific metabolite biomarkers and metabolic pathways underlying MBCT's therapeutic effects in adolescent depression remain unclear. This study aims to identify potential metabolite biomarkers and metabolic regulation pathways associated...
Despite growing interest in mindfulness-based interventions (MBI) for Generalized Anxiety Disorder (GAD), robust evidence for their adjunctive use alongside first-line pharmacotherapy is scarce. This study aimed to evaluate the efficacy of MBI as adjunct to pharmacotherapy in adults with GAD, assessing multidimensional outcomes. In this randomized controlled trial, 106 adults diagnosed with...
This study aimed to evaluate the effects of a Mindfulness-Based Stress Reduction (MBSR) program on depression, anxiety, stress, and hopelessness among parents of children with autism (Autism Spectrum Disorder [ASD]). A pre-test-post-test, parallel-group randomized controlled trial was conducted in two institutions providing education for children with ASD in Konya, Türkiye. The sample included...
Depression is a common complication after stroke. Although prior studies suggest that mindfulness-based stress reduction (MBSR) may alleviate depressive symptoms in post-stroke patients, the evidence remains inconclusive. This meta-analysis aimed to synthesize randomized controlled trials (RCTs) to evaluate the effects of MBSR on depressive symptoms after stroke. PubMed, Web of Science, Embase,...
Depression constitutes a major global public health burden, with university students exhibiting a disproportionately high prevalence of depressive symptoms. Although Mindfulness-Based Stress Reduction (MBSR) has demonstrated efficacy in alleviating depressive symptomatology, its underlying neurobiological mechanisms remain incompletely understood. This randomized controlled trial investigated...
This study aimed to evaluate the impact of an 8-week Mindfulness-Based Stress Reduction (MBSR) program on sleep quality and academic stress among Chinese school adolescents. A total of 46 students were recruited and randomly assigned to either the experimental group (n=22), which participated in the 8-week MBSR program, or the control group (n=24), which received no intervention. Assessments...
Brief mindfulness meditation induction effectively reduces addictive behaviors in clinical populations, yet their impact on non-addicted individuals remains unclear. This study investigated whether brief mindfulness practice amplifies alcohol enjoyment and consumption in healthy young adults. Across two randomized controlled trials (Study 1:N = 67; Study 2:N = 89), participants with low-risk...
Mindfulness meditation is a robust and rapidly growing area of inquiry in the psychological sciences. However, core questions remain about how mindfulness develops, how it exerts its effects, and what conditions amplify or attenuate these effects. We argue that empirical research on mindfulness has predominantly relied on reductionist decomposition-a foundational scientific approach that...
The successful execution of time-based prospective memory (TBPM) tasks demands self-initiation attentional resources. Mindfulness meditation can enhance attention, which may promote TBPM performance. This study investigates whether mindfulness meditation can facilitate TBPM via the improvement of attentional resources and whether such facilitation is modulated by time-monitoring conditions. The...
Clinical nurses face notable chronic stress due to work-related stressors, exacerbated by the COVID-19 pandemic, leading to somatic symptoms and low-grade inflammation. Mindfulness meditation has shown promise in reducing stress and improving health outcomes, but its effects on somatic symptoms and inflammatory biomarkers in nurses remain underexplored. To assess the impact of mindfulness...