Page 72 of 347: studies 711 to 720 of 3,461, newest first. Back to the MDMA overview
Journal watch May 18, 2018 Peter Roy‐Byrne
Current treatments for chronic post-traumatic stress disorder (PTSD) have limited efficacy. In a two-stage, phase 2 study (funded by a nonprofit
Journal of Psychopharmacology May 7, 2018 Balázs Szigeti, Adam Winstock, David Erritzøe et al. 17 citations
BACKGROUND: Neuroimaging studies imply that the regular use of ±3,4-methylenedioxymethamphetamine (MDMA), the major constituent of ecstasy pills, alters the brain's serotonergic system in a dose-dependent manner. However, the relevance of these findings remains unclear due to limited knowledge about the ecstasy/MDMA use pattern of real-life users. AIMS: We examined the representativeness of...
Neuroscience May 1, 2018 Francesca Romana Rizzo, Mauro Federici, Nicola Biagio Mercuri
An increase of extracellular dopamine (DA) has been implicated in the psychostimulant properties of 3,4-methylenedioxymethamphetamine (MDMA). Although this drug has been reported to affect the DA uptake transporter (DAT), it might activate other mechanisms to regulate the outflow of DA in the brain. Our aim was to examine the overall effects of MDMA on the release of DA in the striatum. We...
The Lancet Psychiatry May 1, 2018 Michael C Mithoefer, Ann T Mithoefer, Allison A. Feduccia et al. 443 citations
Background: Post-traumatic stress disorder (PTSD) is prevalent in military personnel and first responders, many of whom do not respond to currently available treatments. This study aimed to assess the efficacy and safety of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for treating chronic PTSD in this population. Methods: We did a randomised, double-blind, dose-response,...
Therapeutic Hypothermia and Temperature Management April 25, 2018 Fritz‐patrick Jahns, Antonine Pineau Mitchell, Georg Auzinger 30 citations
Hyperpyrexia is a well-documented adverse effect of 3,4-methylenedioxymethamphetamine (MDMA) and is associated with a poor prognosis. There are currently limited published records of patients surviving a pyrexia of or greater than 43°C after MDMA intake. Rapid cooling and multiorgan support in an intensive care setting may offer patients the best chance of recovery. We present the case of a...
bioRxiv Preprint Server April 16, 2018 Eric Edsinger, Gül Dölen 1 citation preprint
Human and octopus lineages are separated by over 500 million years of evolution, and show divergent anatomical patterns of brain organization. Moreover, while humans exhibit highly complex social behaviors, octopuses are thought to be largely asocial and solitary. Despite these differences, growing evidence suggests that ancient neurotransmitter systems are shared across vertebrate and...
BMJ Case Reports April 7, 2018 Nonyelum Evangeline Obiechina, Ahrane Jayakumar, Yusra Khan et al.
MDMA (3,4-methylenedioxymethamphetamine) or 'Ecstasy' is an illicit drug frequently used by young people at parties and 'raves'. It is readily available in spite of the fact that it is illegal.1 It is perceived by a lot of young people as being 'harmless', but there have been a few high-profile deaths associated with its use.2 Known side effects of MDMA include hyperthermia, rhabdomyolysis,...
English language notes April 1, 2018 Nathan Wolski
Abstract: According to the Zohar, the most important work of the classical Kabbalah, in prayer the soul of the mystic ascends through seven celestial halls or palaces as part of its quest to unify the male and female aspects of divinity, and thereby stimulates Ein Sof, the infinite aspect of divinity to pour down its bounty. As the soul ascends through the halls—diverse qualities of being,...
The International Journal of Neuropsychopharmacology April 1, 2018 Michael D. Wunderli, Matthias Vonmoos, Lorena Treichler et al.
The empathogen 3,4-methylenedioxymethamphetamine (MDMA) is the prototypical prosocial club drug inducing emotional openness to others. It has recently been shown that acutely applied 3,4-MDMA in fact enhances emotional empathy and prosocial behavior, while it simultaneously decreases cognitive empathy. However, the long-term effects of 3,4-MDMA use on socio-cognitive functions and social...
Neurotoxicity Research April 2018 Anna Maria Górska, Katarzyna Kamińska, Agnieszka Wawrzczak-Bargieła et al.
MDMA (3,4-methylenedioxymethamphetamine) is a psychostimulant popular as a recreational drug because of its effect on mood and social interactions. MDMA acts at dopamine (DA) transporter (DAT) and serotonin (5-HT) transporter (SERT) and is known to induce damage of dopamine and serotonin neurons. MDMA is often ingested with caffeine. Caffeine as a non-selective adenosine A1/A2A receptor...