O interesse científico pelos psicodélicos como alternativa terapêutica para transtornos mentais tem crescido expressivamente nas últimas duas décadas, impulsionado por ensaios clínicos que demonstram resultados promissores em pacientes com depressão resistente ao tratamento, transtorno de estresse pós-traumático, ansiedade relacionada a doenças graves e transtornos por uso de substâncias....
This project will use a PRISMA-guided systematic review and meta-analysis to examine whether age moderates anxiety and depression outcomes following psychoactive-assisted treatments. In this review, psychoactive-assisted treatments are defined as clinically structured treatments involving classic serotonergic psychedelics, MDMA, ketamine, or esketamine. The term is intentionally broader than...
BMC Public HealthJuly 17, 2026Gökhan Vatansever, Benjamin Collins, Harun Tulunay et al.
BACKGROUND: Chemsex, a form of sexualised substance use, is using psychoactive substances to enhance sexual pleasure. It is most commonly practised by gay, bisexual and other men who have sex with men, transgender and non-binary people. Although chemsex has been increasingly discussed globally, it remains insufficiently studied in many societies due to the stigma and criminalisation of some...
Objective: The objective of this narrative review is to understand what forms of spirituality screening and spiritual support are available to individuals with serious or life-threating illness involved in psychedelic-assisted therapies. Introduction: In addition to physical pain related to disease and treatment processes, people encountering serious illness frequently experience psychological...
Background. Post-Traumatic Stress Disorder (PTSD) is an important public health challenge typically treated with trauma-focused psychotherapy and Selective Serotonin Reuptake Inhibitors (SSRIs). However, high rates of residual symptoms associated with these standard treatments have led to a renewed interest in psychedelic-assisted therapies. Aim. This review attempts to examine emerging...
Background: When administered alongside monitoring and support, psilocybin has shown promise in the treatment of multiple psychiatric conditions. However, the contribution and nature of participant support in the context of psychedelic trials are much debated. Aims: We sought to further illustrate the structure and format of the monitoring and support used in Compass Pathfinder Ltd (Compass)...
Medycyna PaliatywnaJuly 15, 2026Maciej Sulerzycki, Katarzyna Pomykała, Katarzyna Giemza et al.
In recent years, there has been a growing interest in the therapeutic use of psychedelics. In palliative medicine, they are being considered as an alternative approach to treating depression, existential distress, and chronic pain conditions. This review presents current literature on the use of psychedelic substances such as psilocybin, lysergic acid diethylamide,...
PTSD is a prevalent and debilitating condition, for which many individuals do not seek or complete treatment. As new PTSD treatments are being evaluated, such as psychedelic-assisted therapies, it’s important to understand the preferences of individuals for whom these treatments are being developed. To date, no research has directly compared preferences for psychedelic-assisted therapies...
New psychoactive substances (NPSs) often emerge on the illicit drug market with limited pharmacological or toxicological data. Synthetic cathinones are the second largest NPS group, often mimicking the effects of classical stimulants such as cocaine and methylenedioxymethamphetamine (MDMA). Such stimulants primarily target dopamine (DAT), norepinephrine (NET) and serotonin (SERT) transporters,...
6-(2-aminopropyl)benzofuran (6-APB) is a recreational drug that is structurally similar to MDMA. Very little is known about the behavioral effects of 6-APB or its dose-effect relationship in vivo. As the popularity of new psychoactive substances (NPS), such as 6-APB, increases due to their unscheduled status and easy availability, it is important to understand the potential benefits and/or...