Neuropsychopharmacology
April 1994
U D McCann, A Ridenour, Y Shaham et al.
(+/-)3,4-Methylenedioxymethamphetamine (MDMA; "Ecstasy"), an increasingly popular recreational drug, is known to damage brain serotonin 5-hydroxytryptamine (5-HT) neurons in experimental animals. Whether MDMA is neurotoxic in humans has not been established. Thirty MDMA users and 28 controls were admitted to a controlled inpatient setting for measurement of biologic and behavioral indexes of...
Psychiatric Annals
March 1, 1994
David M. Mcdowell, Herbert D. Kleber
75 citations
MDMA has been effectively illegal since it was classified as a Schedule I drug in July 1985.
Psychiatric Annals
March 1, 1994
Robert L. Dupont, Karl Verebey
1 citation
LSD and Ecstasy and other hallucinogenic drugs (especially psilocybin mescaline) are in an anomalous position as frequently abused, widely available illicit drugs that are rarely identified in drug tests.
Pharmacology, Biochemistry, and Behavior
February 1994
A G Romano, John A. Harvey
The rate of associative learning was assessed in the presence of saline versus methylenedioxymethamphetamine (MDMA) at doses of 0.95, 1.9, and 3.8 mg/kg. The conditioned stimuli (CSs) were lights and tones and the unconditioned stimulus (US) was a corneal air puff. Learning was enhanced by all but the highest dose of drug tested, and the enhancement was most pronounced when light was used as...
Pharmacology, Biochemistry, and Behavior
February 1994
H Q Lin, Iain S. Mcgregor, D M Atrens et al.
A series of experiments examined the role of dopamine in the conditioned taste aversion (CTA) produced by 3,4-methylenedioxymethamphetamine (MDMA) and d-amphetamine in rats. The CTA induced by MDMA (1.0 mg/kg) was unaffected by the D1 dopamine receptor antagonist SCH23390 (0.3 or 0.6 mg/kg), the D2 receptor antagonist raclopride (0.3 or 0.6 mg/kg), SCH23390 and raclopride combined (both 0.3 or...
Comparative drama
1994
Natalie Crohn Schmitt
1 COMPABATIVE i ama Volume 28Summer 1994Number 2 Ecstasy and Peak-Experience: W. B. Yeats, Marghanita Laski, and Abraham Maslow Natalie Crohn Schmitt In a world beset by realism, science, and the workaday, W. B. Yeats set about inventing a dramatic form to induce ecstatic experience in his audience and dedicated his long dramatic career to that effect.1 He thought of his art, he said, as but...
Life Sciences
1994
J E Sprague, X Huang, A Kanthasamy et al.
Treatment of rats with serotonin (5-HT) precursors tryptophan (TRP, 400 mg/kg) and 5-hydroxytryptophan (5-HTP, 50 mg/kg) was shown to attenuate MDMA (20 mg/kg) induced serotonergic neurotoxicity as measured by [3H]-paroxetine binding in the striatum, hippocampus, and frontal cortex of the rat brain. Hippocampal 5-HT and 5-HIAA levels were also indicative of the protective effects of TRP and...
University of Regensburg Publication Server
1994
Norbert Wodarz, J. Böning
1 citation
Deren Mitglieder führen seit 1988 mit besonderen Lizenzen psycholytische Therapien mit LSD und MDMA durch.
Journal of Psychopharmacology
1994
Hugh Series, Sietske Boeles, Eluned Dorkins et al.
44 citations
Two case reports are presented of significant psychiatric disorders associated with ingestion of 'Ecstasy' (3,4-methylenedioxymethamphetamine), a recreational drug whose use appears to be increasing. In one case, the patient developed a brief paranoid psychosis which recurred and persisted for at least a month after he took a second dose of the drug. In the other, the patient experienced...
British Journal of Pharmacology
1994
María Isabel Colado, A.r. Green
62 citations
1. An investigation has been made in rats into the neurotoxic effect of the relatively selective 5-hydroxytryptamine (5-HT) neurotoxin, 3,4-methylenedioxymethamphetamine (MDMA or 'Ecstasy') using chlormethiazole and dizocilpine, both known neuroprotective compounds and also gamma-butyrolactone, ondansetron and pentobarbitone. 2. Administration of MDMA (20 mg kg-1, i.p.) resulted in a 50% loss...