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Anthropology of Consciousness October 1, 1991 Michael Winkelman
This paper reviews some of the evidence indicating that hallucinogens or psychedelic substances have therapeutic effects. The general character hallucinogen use in non‐ Western societies is briefly reviewed to present data about the characteristic beliefs and uses associated with these substances. Evidence for therapeutic effectiveness is addressed from several perspectives: the findings from...
Journal of Medicinal Chemistry May 1, 1991 Michael P. Johnson, Stewart Frescas, Robert Oberlender et al. 53 citations
The racemate and the enantiomers of 1-(3-methoxy-4-methyphenyl)-2- aminopropane (6) and racemic 5-methoxy-6-methyl-2-aminoindan (11) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Both 6 and 11 were found to substitute with high potency in 3,4-(methylenedioxy)methamphetamine (1) and (S)-1-(1,3-benzodioxol-5-yl)-2-(methylamino)butane (2) trained rats. In...
BMJ March 23, 1991 Philip Mcguire, Thomas Fahy 128 citations
Methylenedioxymetamphetamine (MDMA, "ecstasy") is a hallucinogenic amphetamine that combines the effects of amphetamines and lysergic acid diethylamide (LSD) and has become increasingly popular in the United Kingdom.We report two cases of chronic paranoid psychoses after heavy misuse of this drug. Case reports CASE I
Psychopharmacology 1991 Elaine Sanders‐bush, M Breeding
Behavioral, electrophysiological and biochemical evidence suggest that the 5HT2 receptor plays a role in the action of hallucinogenic agents. Considering the structural and functional similarities between the 5HT2 and 5HT1C receptors, we hypothesized that the 5HT1C receptor may also be an important site of action of hallucinogens. The present manuscript evaluates this hypothesis by examining...
Journal of Medicinal Chemistry 1991 David E. Nichols, Scott E. Snyder, Robert Oberlender et al. 45 citations
Two 2,3-dihydrobenzofuran analogues of hallucinogenic amphetamines were prepared and evaluated for activity in the two-lever drug-discrimination paradigm in rats trained to discriminate saline from LSD tartrate (0.08 mg/kg) and for the ability to displace [125I]-(R)-DOI [( 125I]-(R)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) from rat cortical homogenate 5-HT2 receptors. The compounds,...
Journal of Religion and Health 1991 Christopher M. Bache 6 citations
This study uses a model of consciousness derived from LSD-assisted psychotherapy to illumine an enigmatic set of painful experiences that occur on the mystic's path known in Western circles as the "dark night." It argues that the dark night experiences described in John of the Cross's classic workDark Night of the Soul can be conceptualized in terms of Stanislav Grofs category of "perinatal...
Annals of the New York Academy of Sciences October 1, 1990 Milt Teitler, Sigrun Leonhardt, Nathan M. Appel et al. 33 citations
The data presented herein appear to strongly implicate the brain 5HT2 receptor as the site-of-action of the hallucinogenic PIAs and LSD. If so, this discovery represents a major step in understanding the molecular pharmacology of hallucinogenic drugs. Using radioactive hallucinogenic drugs, detailed properties of brain 5HT2 receptors indicating the interaction of 5HT2 receptors with GTP-binding...
Emergency medicine clinics of North America August 1, 1990 D G Spoerke, A H Hall
The plants described earlier are only a few of those that can be misused. Most have effects similar to those of more popular synthetic drugs but can cause unpleasant side effects and unpredictable results. Identification of the offending botanic agent can be problematic. These plants are still used because most are legal to possess, and they do produce desired hallucinogenic and stimulant...
Naunyn-Schmiedeberg's Archives of Pharmacology June 1, 1990 W Löscher, U Witte, G Fredow et al. 48 citations
In pigs, the serotonin-2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), 0.8 mg/kg, induced "psychotic" behaviour (e.g., grimacing, backward locomotion, blank stare) and a muscular syndrome, which is known as malignant hyperthermia (MH) in pigs and humans. This syndrome is characterized by generalized skeletal muscle rigidity, leading to an increase in body...
Journal of Medicinal Chemistry February 1, 1990 David E. Nichols, William K. Brewster, Michael P. Johnson et al. 83 citations
Four cyclic analogues of the psychoactive phenethylamine derivative 3,4-(methylenedioxy)amphetamine were studied. These congeners, 5,6- and 4,5-(methylenedioxy)-2-aminoindan (3a and 4a, respectively), and 6,7- and 5,6-(methylenedioxy)-2-aminotetralin (3b and 4b, respectively) were tested for stimulus generalization in the two-lever drug-discrimination paradigm. Two groups of rats were trained...