2,3-Dihydrobenzofuran analogs of hallucinogenic phenethylamines
Journal of Medicinal Chemistry 1991 David E. Nichols, Scott E. Snyder, Robert Oberlender et al. 45 citations
Two 2,3-dihydrobenzofuran analogues of hallucinogenic amphetamines were prepared and evaluated for activity in the two-lever drug-discrimination paradigm in rats trained to discriminate saline from LSD tartrate (0.08 mg/kg) and for the ability to displace [125I]-(R)-DOI [( 125I]-(R)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane) from rat cortical homogenate 5-HT2 receptors. The compounds,...