Although the synthetic cathinone 4-methylmethcathinone (4-MMC, mephedrone) has been a subject of intensive research investigation, the pharmacological mechanisms involved in its interoceptive stimulus effects have yet to be fully characterized. The present study employed drug discrimination methods in rats to compare the interoceptive stimulus properties of two different training doses of 4-MMC...
This paper considers the pleasures of psychedelic drugs and proposes a Deleuzian understanding of drugged pleasures as affects. In spite of a large body of work on psychedelics, not least on their therapeutic potentials, the literature is almost completely devoid of discussions of the recreational practices and pleasures of entheogenic drugs. Yet, most people do not use psychedelics because of...
Abstract Neurophysiological recordings are dominated by arhythmical activity whose spectra can be characterised by power-law functions, and on this basis are often referred to as reflecting scale-free brain dynamics (1/ f β ). Relatively little is known regarding the neural generators and temporal dynamics of this arhythmical behaviour compared to rhythmical behaviour. Here we used Irregularly...
Classic hallucinogens (e.g. psilocybin and LSD) have substantial effects on perception, cognition, and emotion that can often be psychologically challenging, however we know very little regarding the source of significant individual variability that has been observed in the frequency and intensity of challenging experiences (i.e. "bad trips") with psychedelics. Previous clinical and...
Stanislav Grof jest jednym z twórców psychologii transpersonalnej, obok psychoanalizy, behawioryzmu oraz nurtu humanistycznego stanowiącej „czwartą siłę w psychologii”. Pochodzący z Czech naukowiec zasłynął jednak prawdopodobnie bardziej jako pionier w dziedzinie badań nad wpływem LSD na umysł i terapeutycznym jego zastosowaniem. Poza mózg: narodziny, śmierć i transcendencja w psychoterapii to...
BACKGROUND: Novel psychoactive substances (NPS) can be classified based on their safety for use into low-risk and high-risk. High-risk NPS can be either lethal or poisonous. Fatalities can be either pharmacological or behavioural-induced, including suicide and homicide.MATERIALS & METHODS: Observational analysis, including retrospective, were implemented across; Google Trends, PubMed/MedLine...
An eighteen years old female patient of the Caucasian ethnicity from New Zealand, she presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when outdoor due to an oversensitivity to sunlight. However, her pupillary reaction to light (pupillary light reflex) was intact. The patient is a known user of psychedelic substances (entheogens) including LSD,...
Given the plethora of new studies and published papers in the scientific press and the increasingly emerging presence of articles about positive psychedelic experiences appearing in the popular media, there is little doubt that we are in the midst of a Psychedelic Renaissance. The classical psychedelic drugs LSD and psilocybin and the entactogen MDMA are showing promise as tools to assist...
A pressing philosophical problem is how to respond to the existential, anxiety and disenchantment resulting from a naturalistic worldview that eschews transcendent foundations for meaning and value. This problem is becoming more urgent as the popularization of neuroscientific findings renders a disenchanted conception of human beings ever more vivid, compelling, and widespread. I argue that the...
The dynamic correlation between auditory hallucination and monologue, which could not be clinically made clear so far, was brought into existence through the LSD psychotherapeutic situation of chronic hallucinatory schizophrenia. The analysis of monologue and its correlated bodily automovements opens a new way to experimental approach to one aspect of hallucination in schizophrenics. 1....