página 48|Revista de Psiquiatría del Uruguay|Volumen 90 Nº 1 Julio 2026| Psicodélicos en psiquiatría: un modelo multidimensional para el análisis...Resumo Nos últimos anos, o renovado interesse pelo uso medicinal dos psicodélicos adquiriu um caráter hipermidiatizado, estendendo sua presença de contextos clínicos e rituais tradicionais para cenários mais amplos, nos quais os objetivos...
Les mécanismes sous-jacents à la richesse des états de conscience chez l'humain demeurent mal connus. Cette thèse étudie l’organisation temporo-spectro-spatiale des dynamiques neuronales au sein de l'état de référence et des états de conscience modifiés par les psychédéliques. L’étude 1 caractérise la manière dont l'architecture anatomique du cerveau contraint l’activité électrophysiologique,...
L'EncephaleJuly 1, 2026Ana Beatriz Pereira de Oliveira, Matthieu Hein
INTRODUCTION Given the contrasting results available in the literature, the objective of this systematic review was to investigate the specific impact of illicit use of classic psychedelics (psilocybin, LSD, DMT, mescaline) on suicidality (suicidal ideation, suicide planning, suicide attempts, suicides). METHOD According to PRISMA criteria, a systematic review of the literature was carried out...
Mental disorders represent a major global health problem, with depression being one of the most prevalent and disabling conditions worldwide. Growing evidence suggests that the serotonergic system, particularly the 5-HT2A receptor, plays an important role in modulating mood and cognitive processes, constituting a key pharmacological target for several psychoactive compounds. In this study, we...
PsychopharmacologyJuly 1, 2026Sarah Ann Smith, Haseeb Mohammad, Lik Hang N Lee et al.
Interest in psychedelic drugs has increased rapidly because of their potential therapeutic role in psychiatric disorders. Impairments in the sociocognitive skills needed to build and maintain social relationships are prominent features of many psychiatric and neurodevelopmental disorders. Emerging evidence suggests that compounds such as 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid...
Background: Psychedelic microdosing—repeated sub-perceptual doses of lysergic acid diethylamide (LSD) or psilocybin—has attracted scientific interest as a potential mood and cognitive intervention. The evidence base remains methodologically heterogeneous and vulnerable to expectancy bias. Methods: We conducted an umbrella review with narrative synthesis following Joanna Briggs Institute...
With growing research on the use of psychedelics to treat mental health conditions, greater attention to the psychosocial procedures accompanying substance administration is warranted. This scoping review aims to categorize psychosocial protocols used in research involving psychedelics as psychiatric treatment according to their purpose, denomination, format, therapeutic orientation,...
Prophetic or messianic states of consciousness are charged with moral urgency and are active, historical, political, and sometimes infused with ego. In this paper, I inquire into psychedelic micro-messianic phenomenology and revolutionary dynamics through the historical case studies of Allen Ginsberg, Master Irineu, and John Wilson (Moonhead)—figures associated with the diffusion of LSD, Daime...
Journal of Psychiatric ResearchJune 23, 2026Júlio César Claudino Dos Santos, Sofia Januário Bolan, Guilherme Lodetti da Silva et al.
Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition characterized by persistent deficits in social communication and interaction, restricted and repetitive patterns of behavior, and sensory processing alterations, frequently accompanied by anxiety, emotional dysregulation, and other psychiatric comorbidities. Despite advances in behavioral and pharmacological...
This protocol describes a systematic review and meta-analysis assessing the efficacy and safety of classic serotonergic psychedelics and related serotonergic ergoline or lysergamide compounds in cluster headache and migraine. The review will include clinical studies evaluating psilocybin, psilocin, LSD, LSA, DMT/ayahuasca, mescaline, BOL-148 / 2-bromo-LSD / bromolysergide, lisuride,...