Pharmacology, Biochemistry, and Behavior
October 1, 2021
Sara de la Salle, D. Shah, Joëlle Choueiry et al.
Impairments in auditory information processing in schizophrenia as indexed electrophysiologically by P300 deficits during novelty (P3a) and target (P3b) processing are linked to N -methyl- D -aspartate receptor (NMDAR) dysfunction. This study in 14 healthy volunteers examined the effects of a subanesthetic dose of the NMDAR antagonist ketamine on P300 and their relationship to psychomimetic...
Frontiers in Psychiatry
September 10, 2021
Cato M. H. de Vos, Natasha L. Mason, Kim P. C. Kuypers
259 citations
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca, DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive, antidepressant, anxiolytic, and antiaddictive effects suggested to arise from biological changes similar to conventional antidepressants or the rapid-acting substance ketamine. The proposed route is by inducing brain...
bioRxiv Preprint Server
September 2, 2021
Laura De la Fuente, Federico Zamberlán, Hernan Bocaccio et al.
preprint
Even though the fundamental laws of physics are the same when the direction of time is inverted, dissipative systems evolve in the preferred temporal direction indicated by the thermodynamic arrow of time. The fundamental nature of this temporal asymmetry led us to hypothesize its presence in the neural activity evoked by conscious perception of the physical world, and thus its covariance with...
bioRxiv Preprint Server
August 17, 2021
Nicolas Fuentes, Alexis García, Ramón Guevara et al.
preprint
The use of anaesthesia is a fundamental tool in the investigation of consciousness. Anesthesia procedures allow to investigate different states of consciousness from sedation to deep anesthesia within controlled scenarios. In this study we use information quantifiers to measure the complexity of electrocorticogram recordings in monkeys. We apply these metrics to compare different stages of...
Translational Psychiatry
August 15, 2021
Katherine Beck, Atheeshaan Arumuham, Mattia Veronese et al.
Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched healthy controls) using PET imaging with an NMDAR selective ligand, [18F]GE-179, that binds to the ketamine binding site to index its distribution volume...
Experimental and therapeutic medicine
August 5, 2021
Ioana Rădulescu, A. Drăgoi, S. Trifu et al.
In modern society, depression is one of the most common mental illness; however, its pathophysiology is not yet fully understood. A great body of evidence suggests that depression causes changes in neuroplasticity in specific regions of the brain which are correlated to symptom severity, negative emotional rumination as well as fear learning. Depression is correlated with atrophy of neurons in...
Scientific Reports
August 3, 2021
Amelia Dahlén, Mahdi Zarei, Adam Melgoza et al.
High doses of the Cannabis constituent Δ9-tetrahydrocannabinol (THC) increase the risk of psychosis in humans. Highly accessible animal models are needed to address underlying mechanisms. Using zebrafish with a conserved endocannabinoid system, this study investigates the acute effects of THC on adult zebrafish behavior and the mechanisms involved. A concentration-dependent THC-induced...
Neuropharmacology
August 1, 2021
Chrislean Jun Botanas, Raly James Perez Custodio, Hee Jin Kim et al.
13 citations
The newfound antidepressant efficacy of ketamine has provided opportunities for the development of new-generation, rapid-acting, glutamate-based antidepressants. We previously identified that methoxetamine (MXE), a ketamine analog, and an N-Methyl-d-aspartate (NMDA) receptor antagonist, produced rapid and sustained antidepressant effects in mice. MXE (R, S (±)-MXE) is a racemic mixture...
Cells
July 27, 2021
Dasiel O Borroto-Escuela, Patrizia Ambrogini, Manuel Narváez et al.
29 citations
The heteroreceptor complexes present a novel biological principle for signal integration. These complexes and their allosteric receptor–receptor interactions are bidirectional and novel targets for treatment of CNS diseases including mental diseases. The existence of D2R-5-HT2AR heterocomplexes can help explain the anti-schizophrenic effects of atypical antipsychotic drugs not only based on...
Expert Review of Clinical Pharmacology
July 6, 2021
E. Schenberg
Dear Editors, Unblinding is an important confounding in pharmacological research potentially affecting rigor and objectivity of the scientific data underlying evidence-based medicine. Therefore, I want to commend the work by Muthukumaraswamy et al. [1] reporting on this problem in clinical trials with psychedelics (Ketamine, LSD, psilocybin and ayahuasca), which are rapidly becoming a focus of...