Journal of Clinical Psychopharmacology
September 1, 2023
Philip R Wang, Mani Yavi, Holim Lee et al.
Abstract: Background: Approximately one third of individuals with major depressive disorder have treatment-resistant depression (TRD). Glutamatergic modulators such as the N-methyl-d-aspartate receptor antagonist ketamine have rapid and robust antidepressant effects, but their use has been limited by accessibility and route of administration. This open-label pilot study assessed the adjunctive...
September 1, 2023
Fernando Gómez, Ian Philip Barrera, Rodolfo Maytorena-Gutiérrez et al.
1 citation
Please confirm that an ethics committee approval has been applied for or granted: Not relevant (see information at the bottom of this page) Background and Aims Chronic pain presents a significant healthcare burden and can become quite debilitating. The current standards of care for chronic pain include lifestyle management, procedures, and analgesics for acute exacerbations. However, using...
Drug and Alcohol Review
September 1, 2023
Joseph J Palamar
5 citations
It is largely unknown whether adverse effects experienced from recreational drug use affect willingness to use again. This study determined whether adverse effects from select party drugs affect reported willingness to use again in the next month among a high-risk population-people who attend electronic dance music parties at nightclubs or dance festivals. Adults (age ≥ 18) entering...
Molecular Psychiatry
September 1, 2023
Matthew B. Wall, Rebecca Harding, Rayyan Zafar et al.
39 citations
Psychedelic therapy (PT) is an emerging paradigm with great transdiagnostic potential for treating psychiatric disorders, including depression, addiction, post-traumatic stress disorder, and potentially others. 'Classic' serotonergic psychedelics, such as psilocybin and lysergic acid diethylamide (LSD), which have a key locus of action at the 5-HT2A receptor, form the main focus of this...
European Journal of Psychotraumatology
August 29, 2023
Lihong Jiang, Amanda J. F. Tamman, Christopher L. Averill et al.
8 citations
Background: Early trauma predicts poor psychological and physical health. Glutamatergic synaptic processes offer one avenue for understanding this relationship, given glutamate's abundance and involvement in reward and stress sensitivity, emotion, and learning. Trauma-induced glutamatergic excitotoxicity may alter neuroplasticity and approach/avoidance tendencies, increasing risk for...
Frontiers in Pharmacology
August 22, 2023
Mary G. Hornick, Ashley Stefanski
9 citations
The United States is entering its fourth decade of the opioid epidemic with no clear end in sight. At the center of the epidemic is an increase in opioid use disorder (OUD), a complex condition encompassing physical addiction, psychological comorbidities, and socioeconomic and legal travails associated with the misuse and abuse of opioids. Existing behavioral and medication-assisted therapies...
Journal of Psychoactive Drugs
August 21, 2023
Caroline Rutherford, Austin Le, Joseph J Palamar et al.
2 citations
Few epidemiological studies have focused on seasonal variation in the use of common psychedelics and party drugs among nightclub and festival attendees, typically those who attend electronic dance music (EDM) events. We sought to determine whether the use of different drug types varies seasonally within this population. Across 15 seasons from summer 2017 through fall 2022, we surveyed 3,935...
The Journal of Clinical Psychiatry
August 14, 2023
Michael E. Thase
9 citations
Among the greatest unmet needs in major depressive disorder (MDD) is a lack of effective pharmacotherapies for patients who do not respond to first- and second-line antidepressant medications. After decades of muted progress, optimism regarding the future of MDD therapy rose after scientists serendipitously uncovered the antidepressant effects of ketamine. The discovery of ketamine's...
Journal of the American Psychiatric Nurses Association
August 10, 2023
G. Pearson
The use of psychedelic medications to treat the brain disorders associated with psychiatric illness has re-emerged in recent years as a viable treatment option (Grieco et al., 2022). Historically there is evidence of hallucinogenic use in religious and spiritual rituals dating back to 500 B.C. (Begola & Dowben, 2018). The discovery of LSD (lysergic acid diethylamine-25) in Switzerland in 1943...
Harm Reduction Journal
August 9, 2023
Hagit Bonny-Noach, Barak Shapira, Pinchas Baumol et al.
9 citations
Few studies have analyzed harm reduction behaviors and attitudes among rave party attendees. Since the late 1980s, there has been a large Israeli rave scene, also known as 'Nature Parties'. However, only a few studies have been conducted among nature party attendees and almost all of them are from a qualitative perspective. This study's aim was to fill the gap and conduct quantitative research...