Journal of Education, Health and Sport
July 16, 2026
Jakub Bajer, Aleksandra Włodarczyk, Hubert Kulawinek et al.
Background. Post-Traumatic Stress Disorder (PTSD) is an important public health challenge typically treated with trauma-focused psychotherapy and Selective Serotonin Reuptake Inhibitors (SSRIs). However, high rates of residual symptoms associated with these standard treatments have led to a renewed interest in psychedelic-assisted therapies. Aim. This review attempts to examine emerging...
Psychopharmacology
July 14, 2026
Kate A Lawson, Stephen V Mahler
In humans, researchers can readily query the subjective states elicited by drugs of abuse, but no such introspective readout is currently available in rodents. Rats can convey information relevant to their internal states via ultrasonic vocalizations (USVs). We sought to measure USVs and locomotor behavior as parallel behavioral indices of the effects of drugs and ventral tegmental area...
Journal of Psychopharmacology
July 13, 2026
Todd D Gould, Sanjay J. Mathew, Maurizio Fava et al.
The occupancy-driven pharmacology model in psychopharmacology has guided drug discovery and development for decades, whereby the goal is stable receptor occupancy over an extended period with a direct relationship of drug exposure to pharmacodynamic and therapeutic response. Event-driven pharmacology (EDP) is a concept where the acute pharmacodynamic actions of a plastogen, a transient binding...
Expert Review of Neurotherapeutics
July 1, 2026
Stephen Rush, Henry A Nasrallah
Treatment-resistant depression (TRD) represents an unmet challenge, accounting for disproportionate morbidity, disability, and healthcare burden in depression. Limitations of monoaminergic antidepressants have prompted a conceptual shift toward models emphasizing impaired neuroplasticity, synaptic dysfunction, and network dysregulation. This expert review synthesizes preclinical, translational,...
Psychiatry Research
July 1, 2026
Erin Artna, Guneet Sandhu, Noah Chisamore et al.
1 citation
Borderline personality disorder (BPD) is a serious mental illness with high rates of morbidity and stigma; however, successful remission is frequently limited by a paucity of accessible treatment options. In an era of growing interest in psychedelics as novel psychiatric treatment modalities, patients with BPD are often excluded from research due to perceived safety risks, particularly...
Neuropsychiatrie
June 30, 2026
Cielo A Estela-Fernandez, Reem Mohamed Yousif Elsheikh, Dal Bianco Beatrice et al.
Major depressive disorder (MDD) is a heterogeneous, debilitating disorder. A distinct subgroup within the MDD spectrum is identified to have treatment-resistant depression (TRD). There is an impetus to find alternative treatments for TRD to reduce disease burden and improve quality of life. Psychedelics have been used in the treatment of various psychiatric disorders since the 1950s, with...
Journal of Affective Disorders
June 29, 2026
Yao Ge, Lijuan Chen, Yu Shen et al.
Major depressive disorder (MDD) ranks among the foremost contributors to disability worldwide, yet its neurophysiological mechanisms remain poorly understood. Excitation-inhibition (E/I) imbalance has been implicated in MDD pathophysiology, but cortex-wide E/I ratio and its molecular substrates in MDD remain unknown. Resting-state functional magnetic resonance imaging data from 254 MDD patients...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
June 20, 2026
Aline Freyssin, Reina Benabou, Hanna Zoe Müller et al.
Despite recent advances in neuropsychiatry, translational development for many targets remains challenging, particularly when receptors exist as families with complex subunit-dependent pharmacology and safety concerns. This is the case for NMDA receptor (NMDAR) antagonists. R,S-ketamine illustrates this issue: although it produces rapid antidepressant effects in the clinic, its use is limited...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
June 20, 2026
Ewen Kervadec, Pauline Mathieu, Baptiste Fauvel et al.
The renewal of psychedelic medicine has garnered significant scientific interest, with large efforts dedicated to the understanding of the complex subjective experiences induced by these substances. The Altered States of Consciousness (ASC) questionnaire represents the most comprehensive instrument for measuring such experiences yet lacks a validated French translation despite its centrality to...
European Journal of Psychotraumatology
June 15, 2026
V Ursule Taujanskaite, Sunjeev K. Kamboj
Background: State dissociation is commonly assessed using the Clinician Administered Dissociative States Scale (CADSS; 19-items). A briefer CADSS would have many advantages, enabling assessment of transient dissociative states and allowing repeated assessment within short intervals while minimizing participant burden. This is especially relevant in studies of dissociative drugs which cause...